Component

Human PIP5K1C_i4 isoform (700 amino acids)

Human PIP5K1C_i4 isoform (700 amino acids). Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human PIP5K1C_i4 displayed PI4P 5-kinase activity in vitro.

    Human PIP5K1C_i4 isoform (700 amino acids) → Phosphatidylinositol 4-phosphate (PI4P) source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19548880.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8", "start_char": 0, "end_char": 1766, "text_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8"}
    experimental_model
    Human splice-isoform expression, localization and kinase assay
    exposure
    PIP5K1C_i4 and i5 characterization
    limitations
    Isoforms have different localizations; a bulk lipid concentration cannot describe every local pool.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human proteins in cellular expression assays
    plain_language
    This isoform can make PI(4,5)P2 from PI4P.
    primary_references
    [ino-p19548880] Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. (2009). https://pubmed.ncbi.nlm.nih.gov/19548880/ DOI: 10.1042/bj20090638
    tissue_or_cell_type
    Nuclear and vesicular compartments

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 574–585

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human splice-isoform expression, localization and kinase assay · source_derived_draft · unverified_draft

    ### ino-pip5k-i4 Human PIP5K1C_i4 displayed PI4P 5-kinase activity in vitro. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: This isoform can make PI(4,5)P2 from PI4P. organism: Human proteins in cellular expression assays tissue_or_cell_type: Nuclear and vesicular compartments experimental_model: Human splice-isoform expression, localization and kinase assay limitations: Isoforms have different localizations; a bulk lipid concentration cannot describe every local pool. exposure: PIP5K1C_i4 and i5 characterization evidence_span: {"source_cache": "artifacts/inositol-research/19548880.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8", "start_char": 0, "end_char": 1766, "text_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8"} [ino-p19548880] Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. (2009). https://pubmed.ncbi.nlm.nih.gov/19548880/ DOI: 10.1042/bj20090638
    Complete structured claim and evidence

  2. The newly characterized 700-amino-acid PIP5K1C_i4 isoform localized to the nucleus.

    Human PIP5K1C_i4 isoform (700 amino acids) → Nucleus source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19548880.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8", "start_char": 0, "end_char": 1766, "text_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8"}
    experimental_model
    Human splice-isoform expression, localization and kinase assay
    exposure
    PIP5K1C_i4 and i5 characterization
    limitations
    Isoforms have different localizations; a bulk lipid concentration cannot describe every local pool.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human proteins in cellular expression assays
    plain_language
    Where an enzyme works can matter as much as its reaction.
    primary_references
    [ino-p19548880] Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. (2009). https://pubmed.ncbi.nlm.nih.gov/19548880/ DOI: 10.1042/bj20090638
    tissue_or_cell_type
    Nuclear and vesicular compartments

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 600–611

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human splice-isoform expression, localization and kinase assay · source_derived_draft · unverified_draft

    ### ino-pip5k-i4-location The newly characterized 700-amino-acid PIP5K1C_i4 isoform localized to the nucleus. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Where an enzyme works can matter as much as its reaction. organism: Human proteins in cellular expression assays tissue_or_cell_type: Nuclear and vesicular compartments experimental_model: Human splice-isoform expression, localization and kinase assay limitations: Isoforms have different localizations; a bulk lipid concentration cannot describe every local pool. exposure: PIP5K1C_i4 and i5 characterization evidence_span: {"source_cache": "artifacts/inositol-research/19548880.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8", "start_char": 0, "end_char": 1766, "text_sha256": "5ae150d47bf139d7352c8a5a128e0d6b071340f8c47d78700d5f398a549d3cd8"} [ino-p19548880] Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. (2009). https://pubmed.ncbi.nlm.nih.gov/19548880/ DOI: 10.1042/bj20090638
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards