Component
Phthalazine
Phthalazine. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human AOX1 structures and kinetics characterize phthalazine binding and oxidation at its molybdenum active site.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/molybdenum-research/26322824.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c289f1d166c7335431b4d041963accf22af348b4cac506145f2ccef59ca8188", "start_char": 0, "end_char": 1067, "text_sha256": "0c289f1d166c7335431b4d041963accf22af348b4cac506145f2ccef59ca8188"}
- experimental_model
- Human AOX1 structures and steady-state kinetics with substrate and inhibitor
- exposure
- Phthalazine and thioridazine
- limitations
- Specific xenobiotic chemistry; does not establish broad detoxification benefits from molybdenum supplements.
- nutrient_topic
- Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
- organism
- Homo sapiens protein
- plain_language
- AOX1 processes certain nitrogen-containing compounds.
- primary_references
- [mo-p26322824] Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. (2015). https://pubmed.ncbi.nlm.nih.gov/26322824/ DOI: 10.1038/nchembio.1895
- tissue_or_cell_type
- Recombinant purified AOX1
Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 833–844
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human AOX1 structures and steady-state kinetics with substrate and inhibitor · source_derived_draft · unverified_draft
### mo-aox-phthalazine Human AOX1 structures and kinetics characterize phthalazine binding and oxidation at its molybdenum active site. Condition category: normal nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: AOX1 processes certain nitrogen-containing compounds. organism: Homo sapiens protein tissue_or_cell_type: Recombinant purified AOX1 experimental_model: Human AOX1 structures and steady-state kinetics with substrate and inhibitor limitations: Specific xenobiotic chemistry; does not establish broad detoxification benefits from molybdenum supplements. exposure: Phthalazine and thioridazine evidence_span: {"source_cache": "artifacts/molybdenum-research/26322824.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c289f1d166c7335431b4d041963accf22af348b4cac506145f2ccef59ca8188", "start_char": 0, "end_char": 1067, "text_sha256": "0c289f1d166c7335431b4d041963accf22af348b4cac506145f2ccef59ca8188"} [mo-p26322824] Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. (2015). https://pubmed.ncbi.nlm.nih.gov/26322824/ DOI: 10.1038/nchembio.1895
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.