Component
Peptide tyrosine tyrosine / PYY
Peptide tyrosine tyrosine / PYY. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Compared with the control cereal, 4 grams of oat beta-glucan significantly reduced glucose incremental area under the curve at 78 compared with 135 mmol x min/L and insulin at 14.0 compared with 26.8 nmol x min/L and delayed gastric emptying half-time to a geometric mean of 285 minutes compared with 105 minutes, effects not seen after the beta-glucanase-treated arm of the same dose, while subjective appetite, PYY and ghrelin responses were similar to control and pizza intakes at a subsequent unrestricted meal were not significantly different.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/glucan-research/31828287.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "983ae8675d933c4292f9f20059e93db94587b9a570fbfb602f5921f5bd7edd70", "start_char": 0, "end_char": 2204, "text_sha256": "983ae8675d933c4292f9f20059e93db94587b9a570fbfb602f5921f5bd7edd70"}
- experimental_model
- Double-blind randomised crossover trial in 28 participants with gastric emptying, appetite hormones and an unrestricted test lunch
- exposure
- Breakfast meals matched for weight, energy and macronutrients containing 2 or 4 grams of oat beta-glucan, or 4 grams treated with beta-glucanase to reduce molecular weight and viscosity
- limitations
- The beta-glucanase arm is the control that isolates viscosity. The trial was designed around food intake as the primary endpoint and found no effect on it.
- nutrient_topic
- Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. · Beta-glucan
- organism
- Human
- plain_language
- The intact polymer held the meal in the stomach nearly three times longer; the same dose chopped up did nothing.
- primary_references
- [bg-p31828287] Increasing oat β-glucan viscosity in a breakfast meal slows gastric emptying and reduces glycemic and insulinemic responses but has no effect on appetite, food intake, or plasma ghrelin and PYY responses in healthy humans: a randomized, placebo-controlled, crossover trial. (2020). https://pubmed.ncbi.nlm.nih.gov/31828287/ DOI: 10.1093/ajcn/nqz285
- tissue_or_cell_type
- Stomach and postprandial circulation
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomised crossover trial in 28 participants with gastric emptying, appetite hormones and an unrestricted test lunch · source_derived_draft · unverified_draft
### bg-viscosity-slows-the-stomach Compared with the control cereal, 4 grams of oat beta-glucan significantly reduced glucose incremental area under the curve at 78 compared with 135 mmol x min/L and insulin at 14.0 compared with 26.8 nmol x min/L and delayed gastric emptying half-time to a geometric mean of 285 minutes compared with 105 minutes, effects not seen after the beta-glucanase-treated arm of the same dose, while subjective appetite, PYY and ghrelin responses were similar to control and pizza intakes at a subsequent unrestricted meal were not significantly different. Condition category: biomarker_context nutrient_topic: Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. plain_language: The intact polymer held the meal in the stomach nearly three times longer; the same dose chopped up did nothing. organism: Human tissue_or_cell_type: Stomach and postprandial circulation experimental_model: Double-blind randomised crossover trial in 28 participants with gastric emptying, appetite hormones and an unrestricted test lunch limitations: The beta-glucanase arm is the control that isolates viscosity. The trial was designed around food intake as the primary endpoint and found no effect on it. exposure: Breakfast meals matched for weight, energy and macronutrients containing 2 or 4 grams of oat beta-glucan, or 4 grams treated with beta-glucanase to reduce molecular weight and viscosity evidence_span: {"source_cache": "artifacts/glucan-research/31828287.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "983ae8675d933c4292f9f20059e93db94587b9a570fbfb602f5921f5bd7edd70", "start_char": 0, "end_char": 2204, "text_sha256": "983ae8675d933c4292f9f20059e93db94587b9a570fbfb602f5921f5bd7edd70"} [bg-p31828287] Increasing oat β-glucan viscosity in a breakfast meal slows gastric emptying and reduces glycemic and insulinemic responses but has no effect on appetite, food intake, or plasma ghrelin and PYY responses in healthy humans: a randomized, placebo-controlled, crossover trial. (2020). https://pubmed.ncbi.nlm.nih.gov/31828287/ DOI: 10.1093/ajcn/nqz285
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.