Component
PCSK9 transcription
PCSK9 transcription. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Berberine lowered HNF1A-dependent PCSK9 transcription; proteasome inhibition prevented this response.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/25540198.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08c835c28631cd0c79be4e5a602216f8eddcd0f2d0c967074d7c9faf4aa9e446", "start_char": 0, "end_char": 1769, "text_sha256": "08c835c28631cd0c79be4e5a602216f8eddcd0f2d0c967074d7c9faf4aa9e446"}
- experimental_model
- Protein-turnover and proteasome-inhibitor experiments
- exposure
- Berberine, ubiquitin assays and proteasome inhibition
- limitations
- HNF1A protein turnover differs from HNF1A gene transcription. Proteasome inhibitors are experimental probes, not suggested combination treatment.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- Human HepG2 cells; separate mouse and hamster arms
- plain_language
- This route regulates a protein that controls LDL-receptor availability.
- primary_references
- [berberine-p25540198] Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1α protein expression through the ubiquitin-proteasome degradation pathway. (2015). https://pubmed.ncbi.nlm.nih.gov/25540198/ DOI: 10.1074/jbc.m114.597229
- tissue_or_cell_type
- HNF1A and PCSK9 gene regulation
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 480–491
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Protein-turnover and proteasome-inhibitor experiments · source_derived_draft · unverified_draft
### berberine-pcsk9-transcription Berberine lowered HNF1A-dependent PCSK9 transcription; proteasome inhibition prevented this response. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This route regulates a protein that controls LDL-receptor availability. organism: Human HepG2 cells; separate mouse and hamster arms tissue_or_cell_type: HNF1A and PCSK9 gene regulation experimental_model: Protein-turnover and proteasome-inhibitor experiments limitations: HNF1A protein turnover differs from HNF1A gene transcription. Proteasome inhibitors are experimental probes, not suggested combination treatment. exposure: Berberine, ubiquitin assays and proteasome inhibition evidence_span: {"source_cache": "artifacts/berberine-research/25540198.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08c835c28631cd0c79be4e5a602216f8eddcd0f2d0c967074d7c9faf4aa9e446", "start_char": 0, "end_char": 1769, "text_sha256": "08c835c28631cd0c79be4e5a602216f8eddcd0f2d0c967074d7c9faf4aa9e446"} [berberine-p25540198] Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1α protein expression through the ubiquitin-proteasome degradation pathway. (2015). https://pubmed.ncbi.nlm.nih.gov/25540198/ DOI: 10.1074/jbc.m114.597229
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.