Component
Mitochondrial complex I activity in Pank2-mutant mouse brain
Mitochondrial complex I activity in Pank2-mutant mouse brain. See linked evidence for experiment-specific scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Oral 4′-phosphopantetheine corrected the complex I activity defect in globus-pallidus-enriched brain tissue from Pank2-null mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- C57/BL6 Pank2-null mice, both sexes aged 3–6 months, with globus-pallidus-enriched brain dissection; human PKAN cell experiments
- exposure
- Oral 4′-phosphopantetheine in 10% sucrose for 14 days; efficacy regimen 5 micrograms/g body weight (5 mg/kg); both-sex Pank2-null C57/BL6 mice aged 3–6 months; Fig. 2E n=5 per genotype/treatment group.
- limitations
- Biochemical rescue in mice, not a human efficacy result or proof of intact blood–brain-barrier delivery. The tissue was GP-enriched, not purified GP. Loss of Pank2 is machinery impairment, not dietary B5 withdrawal.
- nutrient_topic
- Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
- organism
- Mus musculus
- plain_language
- A downstream intermediate improved a mitochondrial enzyme measurement in this genetic mouse model.
- primary_references
- [b5-bio-salvage2019] 4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. (2019). https://pubmed.ncbi.nlm.nih.gov/31660701/ DOI: 10.15252/emmm.201910489
- tissue_or_cell_type
- Globus-pallidus-enriched brain region; crude dissection also included neighboring structures
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 782–793
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · C57/BL6 Pank2-null mice, both sexes aged 3–6 months, with globus-pallidus-enriched brain dissection; human PKAN cell experiments · source_derived_draft · unverified_draft
### b5-bio-pank2-model-complex-i-rescue Oral 4′-phosphopantetheine corrected the complex I activity defect in globus-pallidus-enriched brain tissue from Pank2-null mice. Condition category: machinery_impairment nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A downstream intermediate improved a mitochondrial enzyme measurement in this genetic mouse model. organism: Mus musculus tissue_or_cell_type: Globus-pallidus-enriched brain region; crude dissection also included neighboring structures experimental_model: C57/BL6 Pank2-null mice, both sexes aged 3–6 months, with globus-pallidus-enriched brain dissection; human PKAN cell experiments limitations: Biochemical rescue in mice, not a human efficacy result or proof of intact blood–brain-barrier delivery. The tissue was GP-enriched, not purified GP. Loss of Pank2 is machinery impairment, not dietary B5 withdrawal. exposure: Oral 4′-phosphopantetheine in 10% sucrose for 14 days; efficacy regimen 5 micrograms/g body weight (5 mg/kg); both-sex Pank2-null C57/BL6 mice aged 3–6 months; Fig. 2E n=5 per genotype/treatment group. cross_nutrient: false [b5-bio-salvage2019] 4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. (2019). https://pubmed.ncbi.nlm.nih.gov/31660701/ DOI: 10.15252/emmm.201910489
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.