Component

Oral rehydration solutions (formulation specified per study)

Oral rehydration solutions (formulation specified per study). Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Hyponatremia below 130 mmol/L occurred in 29/142 versus 16/150 participants receiving reduced-osmolarity versus standard ORS; affected participants were symptom-free.

    Oral rehydration solutions (formulation specified per study) → Plasma or serum sodium concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/sodium-research/10440307.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969", "start_char": 0, "end_char": 2141, "text_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969"}
    experimental_model
    Randomized double-blind comparison in 300 adults with severe cholera
    exposure
    Reduced-osmolarity versus then-standard WHO oral rehydration solution
    limitations
    Historical formulation comparison; not a current formulation recommendation. Both sodium and other solution properties changed; no isolated sodium effect.
    nutrient_topic
    Sodium research collection; topical membership is not evidence of a direct dietary effect. · Sodium
    organism
    Human
    plain_language
    Replacing fluid is not just replacing water: solution composition affected blood sodium.
    primary_references
    [sodium-p10440307] Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial. CHOICE study group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440307/ DOI: 10.1016/s0140-6736(98)09332-5
    tissue_or_cell_type
    Intestinal fluid loss and serum sodium
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17) · lines 1045–1056

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind comparison in 300 adults with severe cholera · source_derived_draft · unverified_draft

    ### sodium-ors-sodium Hyponatremia below 130 mmol/L occurred in 29/142 versus 16/150 participants receiving reduced-osmolarity versus standard ORS; affected participants were symptom-free. Condition category: biomarker_context nutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Replacing fluid is not just replacing water: solution composition affected blood sodium. organism: Human tissue_or_cell_type: Intestinal fluid loss and serum sodium experimental_model: Randomized double-blind comparison in 300 adults with severe cholera limitations: Historical formulation comparison; not a current formulation recommendation. Both sodium and other solution properties changed; no isolated sodium effect. exposure: Reduced-osmolarity versus then-standard WHO oral rehydration solution evidence_span: {"source_cache": "artifacts/sodium-research/10440307.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969", "start_char": 0, "end_char": 2141, "text_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969"} [sodium-p10440307] Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial. CHOICE study group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440307/ DOI: 10.1016/s0140-6736(98)09332-5
    Complete structured claim and evidence

  2. The ORS groups did not differ significantly in initial 24-hour stool output, total stool output or diarrhea duration.

    Oral rehydration solutions (formulation specified per study) → Stool output in adult cholera source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/sodium-research/10440307.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969", "start_char": 0, "end_char": 2141, "text_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969"}
    experimental_model
    Randomized double-blind comparison in 300 adults with severe cholera
    exposure
    Reduced-osmolarity versus then-standard WHO oral rehydration solution
    limitations
    Historical formulation comparison; not a current formulation recommendation. Both sodium and other solution properties changed; no isolated sodium effect.
    nutrient_topic
    Sodium research collection; topical membership is not evidence of a direct dietary effect. · Sodium
    organism
    Human
    plain_language
    A lower-osmolarity formulation did not improve those clinical endpoints in this adult cholera trial.
    primary_references
    [sodium-p10440307] Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial. CHOICE study group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440307/ DOI: 10.1016/s0140-6736(98)09332-5
    tissue_or_cell_type
    Intestinal fluid loss and serum sodium
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17) · lines 1058–1069

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind comparison in 300 adults with severe cholera · source_derived_draft · unverified_draft

    ### sodium-ors-stool The ORS groups did not differ significantly in initial 24-hour stool output, total stool output or diarrhea duration. Condition category: biomarker_context nutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A lower-osmolarity formulation did not improve those clinical endpoints in this adult cholera trial. organism: Human tissue_or_cell_type: Intestinal fluid loss and serum sodium experimental_model: Randomized double-blind comparison in 300 adults with severe cholera limitations: Historical formulation comparison; not a current formulation recommendation. Both sodium and other solution properties changed; no isolated sodium effect. exposure: Reduced-osmolarity versus then-standard WHO oral rehydration solution evidence_span: {"source_cache": "artifacts/sodium-research/10440307.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969", "start_char": 0, "end_char": 2141, "text_sha256": "cd7239d3f0a151f53930364ba35b974cd938a67bc4282e4b67a02e24f68e9969"} [sodium-p10440307] Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial. CHOICE study group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440307/ DOI: 10.1016/s0140-6736(98)09332-5
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards