Component
Ophthalmoplegia
Impaired eye movement measured clinically.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Correcting hypomagnesemia in the 1974 patient coincided with clearing of ophthalmoplegia.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Magnesium availability supports vitamin B1 activation or cofactor use in the specified preparation; this does not establish a dietary threshold or universal treatment failure.
- experimental_model
- Three acute Wernicke-Korsakoff patients: two normomagnesemic and one hypomagnesemic; serial blood transketolase and clinical assessment.
- limitations
- Uncontrolled within-patient sequence; no isolated enzyme mechanism established.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Homo sapiens
- plain_language
- Eye-movement symptoms improved during magnesium correction after a delayed B1 response.
- primary_references
- [traviesa-1974-thiamine] Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy (1974). https://pubmed.ncbi.nlm.nih.gov/4420329/ DOI: 10.1136/jnnp.37.8.959
- tissue_or_cell_type
- Clinical neurological examination
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 747–757
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three acute Wernicke-Korsakoff patients: two normomagnesemic and one hypomagnesemic; serial blood transketolase and clinical assessment. · source_derived_draft · unverified_draft
### mg-thiamine-ocular-recovery Correcting hypomagnesemia in the 1974 patient coincided with clearing of ophthalmoplegia. Condition category: nutrient_deficiency nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Eye-movement symptoms improved during magnesium correction after a delayed B1 response. organism: Homo sapiens tissue_or_cell_type: Clinical neurological examination experimental_model: Three acute Wernicke-Korsakoff patients: two normomagnesemic and one hypomagnesemic; serial blood transketolase and clinical assessment. limitations: Uncontrolled within-patient sequence; no isolated enzyme mechanism established. cross_nutrient: Magnesium availability supports vitamin B1 activation or cofactor use in the specified preparation; this does not establish a dietary threshold or universal treatment failure. [traviesa-1974-thiamine] Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy (1974). https://pubmed.ncbi.nlm.nih.gov/4420329/ DOI: 10.1136/jnnp.37.8.959
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.