Component
Olestra sucrose polyester mixture
Olestra sucrose polyester mixture. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Olestra lowered serum lycopene by 12 weeks, persisting after cholesterol or BMI adjustment; the multivitamin did not prevent this.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/lycopene-research/15930452.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a90148eb83ff18442e37f9fd5ed31f44acbf8d7616ef05ff1e65e6e2d64e84f", "start_char": 0, "end_char": 1595, "text_sha256": "3a90148eb83ff18442e37f9fd5ed31f44acbf8d7616ef05ff1e65e6e2d64e84f"}
- experimental_model
- Randomized 36-week controlled diet study
- exposure
- Olestra substituted for one-third of fat energy; daily multivitamin and vitamin-E-fortified olestra
- limitations
- Exposure-specific depletion, not an established lycopene deficiency syndrome; reference-range limits are not clinical deficiency thresholds.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human, 37 healthy men
- plain_language
- Replacing dietary fat with a nonabsorbed substitute changed carotenoid exposure.
- primary_references
- [lycopene-p15930452] Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoids. (2005). https://pubmed.ncbi.nlm.nih.gov/15930452/ DOI: 10.1093/jn/135.6.1456
- tissue_or_cell_type
- Serum carotenoids and fat-soluble vitamins
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 858–869
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized 36-week controlled diet study · source_derived_draft · unverified_draft
### lycopene-olestra-lycopene Olestra lowered serum lycopene by 12 weeks, persisting after cholesterol or BMI adjustment; the multivitamin did not prevent this. Condition category: biomarker_context nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Replacing dietary fat with a nonabsorbed substitute changed carotenoid exposure. organism: Human, 37 healthy men tissue_or_cell_type: Serum carotenoids and fat-soluble vitamins experimental_model: Randomized 36-week controlled diet study limitations: Exposure-specific depletion, not an established lycopene deficiency syndrome; reference-range limits are not clinical deficiency thresholds. exposure: Olestra substituted for one-third of fat energy; daily multivitamin and vitamin-E-fortified olestra evidence_span: {"source_cache": "artifacts/lycopene-research/15930452.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a90148eb83ff18442e37f9fd5ed31f44acbf8d7616ef05ff1e65e6e2d64e84f", "start_char": 0, "end_char": 1595, "text_sha256": "3a90148eb83ff18442e37f9fd5ed31f44acbf8d7616ef05ff1e65e6e2d64e84f"} [lycopene-p15930452] Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoids. (2005). https://pubmed.ncbi.nlm.nih.gov/15930452/ DOI: 10.1093/jn/135.6.1456
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.