Component
Dose-normalized serum olanzapine concentration
Dose-normalized serum olanzapine concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Median concentration-to-dose ratio was 6.0 in smokers versus 10.1 nmol/L/mg in nonsmokers.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/37841771.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1f6834b6adcdbbdf02999b1bc5f567b8c0873f393d9b0e80127c887ab8054247", "start_char": 0, "end_char": 1698, "text_sha256": "1f6834b6adcdbbdf02999b1bc5f567b8c0873f393d9b0e80127c887ab8054247"}
- experimental_model
- Cross-sectional therapeutic-concentration study
- exposure
- 37 smokers; comparison with nonsmokers
- limitations
- Observed smoking association, not randomized DIM exposure; confounding and individual variability remain.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- 58 outpatients with schizophrenia
- plain_language
- Smoking had a measured association; equal effects from DIM are not established.
- primary_references
- [dim-p37841771] Association of smoking cigarettes, age, and sex with serum concentrations of olanzapine in patients with schizophrenia. (2023). https://pubmed.ncbi.nlm.nih.gov/37841771/ DOI: 10.11613/bm.2023.030702
- tissue_or_cell_type
- Dose-normalized olanzapine concentrations
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 753–764
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cross-sectional therapeutic-concentration study · source_derived_draft · unverified_draft
### dim-olanzapine-smoking Median concentration-to-dose ratio was 6.0 in smokers versus 10.1 nmol/L/mg in nonsmokers. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Smoking had a measured association; equal effects from DIM are not established. organism: 58 outpatients with schizophrenia tissue_or_cell_type: Dose-normalized olanzapine concentrations experimental_model: Cross-sectional therapeutic-concentration study limitations: Observed smoking association, not randomized DIM exposure; confounding and individual variability remain. exposure: 37 smokers; comparison with nonsmokers evidence_span: {"source_cache": "artifacts/dim-research/37841771.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1f6834b6adcdbbdf02999b1bc5f567b8c0873f393d9b0e80127c887ab8054247", "start_char": 0, "end_char": 1698, "text_sha256": "1f6834b6adcdbbdf02999b1bc5f567b8c0873f393d9b0e80127c887ab8054247"} [dim-p37841771] Association of smoking cigarettes, age, and sex with serum concentrations of olanzapine in patients with schizophrenia. (2023). https://pubmed.ncbi.nlm.nih.gov/37841771/ DOI: 10.11613/bm.2023.030702
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.