Component
Nonvertebral fracture incidence
Study-defined Nonvertebral fracture incidence. Read each linked record for species, exposure and endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
D3 assignment did not significantly reduce nonvertebral fractures (HR0.97; 95% CI0.87–1.07; P=0.50).
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- VITAL ancillary fracture trial; 25, 871 adults; median 5.3 years
- exposure
- D3 2000 IU/day versus placebo; randomized factorial omega 3 allocation; median 5.3 years.
- limitations
- Generally healthy midlife/older adults not selected for deficiency. Does not test treatment of established deficiency rickets or osteomalacia.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- Extra D3 did not reduce this fracture endpoint in the population studied.
- primary_references
- [leboff2022] Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35939577/ DOI: 10.1056/nejmoa2202106
- tissue_or_cell_type
- Clinical skeletal outcomes
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1509–1520
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · VITAL ancillary fracture trial; 25, 871 adults; median 5.3 years · source_derived_draft · unverified_draft
### vd-vital-fracture-nonvertebral D3 assignment did not significantly reduce nonvertebral fractures (HR0.97; 95% CI0.87–1.07; P=0.50). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Extra D3 did not reduce this fracture endpoint in the population studied. organism: Homo sapiens tissue_or_cell_type: Clinical skeletal outcomes experimental_model: VITAL ancillary fracture trial; 25, 871 adults; median 5.3 years limitations: Generally healthy midlife/older adults not selected for deficiency. Does not test treatment of established deficiency rickets or osteomalacia. exposure: D3 2000 IU/day versus placebo; randomized factorial omega 3 allocation; median 5.3 years. cross_nutrient: false [leboff2022] Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35939577/ DOI: 10.1056/nejmoa2202106
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.