Component
NMDA receptor-mediated synaptic excitation
NMDA receptor-mediated synaptic excitation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
NMDA receptor-mediated synaptic excitation was selectively inhibited by ethanol in hippocampal slices from adult rats.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/2158533.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "62f29619272239be27b46fe08d9e439abb782cfe87fdb17351d50bfc0e22aa92", "start_char": 0, "end_char": 1708, "text_sha256": "62f29619272239be27b46fe08d9e439abb782cfe87fdb17351d50bfc0e22aa92"}
- experimental_model
- Extracellular recording in adult rat hippocampal slice
- exposure
- Ethanol applied to synaptic responses
- limitations
- Shows the inhibition is selective for the NMDA component rather than general synaptic depression.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Rat
- plain_language
- It is that one receptor being blocked, not the whole synapse being quietened.
- primary_references
- [alcohol-p2158533] NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. (1990). https://pubmed.ncbi.nlm.nih.gov/2158533/ DOI: 10.1523/jneurosci.10-04-01372.1990
- tissue_or_cell_type
- Hippocampus
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 293–304
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Extracellular recording in adult rat hippocampal slice · source_derived_draft · unverified_draft
### alcohol-nmda-selective NMDA receptor-mediated synaptic excitation was selectively inhibited by ethanol in hippocampal slices from adult rats. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: It is that one receptor being blocked, not the whole synapse being quietened. organism: Rat tissue_or_cell_type: Hippocampus experimental_model: Extracellular recording in adult rat hippocampal slice limitations: Shows the inhibition is selective for the NMDA component rather than general synaptic depression. exposure: Ethanol applied to synaptic responses evidence_span: {"source_cache": "artifacts/alcohol-research/2158533.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "62f29619272239be27b46fe08d9e439abb782cfe87fdb17351d50bfc0e22aa92", "start_char": 0, "end_char": 1708, "text_sha256": "62f29619272239be27b46fe08d9e439abb782cfe87fdb17351d50bfc0e22aa92"} [alcohol-p2158533] NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. (1990). https://pubmed.ncbi.nlm.nih.gov/2158533/ DOI: 10.1523/jneurosci.10-04-01372.1990
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.