Component
Methylated niacin metabolite output
Methylated niacin metabolite output. The model and exposure of each linked claim define its scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After the nicotinamide challenge, urinary and plasma methylated-metabolite outputs were similar across ordinary, low-methionine and adequate-methionine periods despite negative nitrogen balance during restriction.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Nicotinamide (challenge_substrate); N1-methylnicotinamide (methylated_product)
- evidence_span
- {"source_cache": "artifacts/niacin-clinical-sources/swendseid1987.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "9a410f57b23d220c2f97bf589b82b31e6e6f6ca2a7b680c2720e1881a0a71b74", "start_char": 0, "end_char": 1188, "text_sha256": "9a410f57b23d220c2f97bf589b82b31e6e6f6ca2a7b680c2720e1881a0a71b74"}
- experimental_model
- Sequential controlled diets; five men aged 25–32 years
- exposure
- 10-day ordinary diet; 14 days at 285 mg methionine/day; 7 days at 725 mg/day; end-period nicotinamide challenge 102 micromol/kg
- limitations
- Methylated metabolite outputs, not all methylation reactions or tissue SAM, were measured. Four participants achieving final-period nitrogen balance contributed the reported comparison. Short exposure, very small study; no inference of unlimited methyl capacity.
- nutrient_topic
- Niacin research collection; topical membership is not evidence of a direct dietary effect. · Niacin (vitamin B3)
- organism
- Homo sapiens
- plain_language
- Using methyl groups to dispose of nicotinamide did not automatically exhaust that capacity during this short low-methionine study.
- primary_references
- [nia-clin-swendseid1987] Methylated niacin derivatives in plasma and urine after an oral dose of nicotinamide given to subjects fed a low-methionine diet. (1987). https://pubmed.ncbi.nlm.nih.gov/2957911/ DOI: 10.1093/ajcn/46.3.496
- tissue_or_cell_type
- Urine, plasma and nitrogen balance
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Niacin: NAD metabolism, deficiency and nutrient interactions (2026-09-17) · lines 1177–1189
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential controlled diets; five men aged 25–32 years · source_derived_draft · unverified_draft
### nia-clin-methionine-output-preserved After the nicotinamide challenge, urinary and plasma methylated-metabolite outputs were similar across ordinary, low-methionine and adequate-methionine periods despite negative nitrogen balance during restriction. Condition category: nutrient_deficiency nutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Using methyl groups to dispose of nicotinamide did not automatically exhaust that capacity during this short low-methionine study. organism: Homo sapiens tissue_or_cell_type: Urine, plasma and nitrogen balance experimental_model: Sequential controlled diets; five men aged 25–32 years limitations: Methylated metabolite outputs, not all methylation reactions or tissue SAM, were measured. Four participants achieving final-period nitrogen balance contributed the reported comparison. Short exposure, very small study; no inference of unlimited methyl capacity. exposure: 10-day ordinary diet; 14 days at 285 mg methionine/day; 7 days at 725 mg/day; end-period nicotinamide challenge 102 micromol/kg cross_nutrient: Nicotinamide (challenge_substrate); N1-methylnicotinamide (methylated_product) evidence_span: {"source_cache": "artifacts/niacin-clinical-sources/swendseid1987.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "9a410f57b23d220c2f97bf589b82b31e6e6f6ca2a7b680c2720e1881a0a71b74", "start_char": 0, "end_char": 1188, "text_sha256": "9a410f57b23d220c2f97bf589b82b31e6e6f6ca2a7b680c2720e1881a0a71b74"} [nia-clin-swendseid1987] Methylated niacin derivatives in plasma and urine after an oral dose of nicotinamide given to subjects fed a low-methionine diet. (1987). https://pubmed.ncbi.nlm.nih.gov/2957911/ DOI: 10.1093/ajcn/46.3.496
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.