Component
Neonatal zinc deficiency
Reported infant zinc-deficiency phenotype; cause and exposure are specified in linked evidence.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
A mother carrying W152R and S296L on different SLC30A2 alleles had a reported greater-than-90% reduction in milk zinc; her breastfed infant developed severe zinc deficiency.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Maternal zinc secretion determines a source of infant zinc supply.
- evidence_span
- {"source_cache": "artifacts/zinc-transport-sources/23741301-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "b422d27e8731293ae1597e65a72d9a6f6c1a161b7adaff3f114ee23f0e95408a"}
- experimental_model
- Human mother–infant clinical genetic observations
- exposure
- Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting.
- limitations
- Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- Two different maternal variants were linked to profoundly low milk zinc.
- primary_references
- [zinc-trans-23741301] Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. (2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045
- tissue_or_cell_type
- Maternal milk and breastfed infant
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 571–583
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human mother–infant clinical genetic observations · source_derived_draft · unverified_draft
### zinc-trans-milk-compound-variants A mother carrying W152R and S296L on different SLC30A2 alleles had a reported greater-than-90% reduction in milk zinc; her breastfed infant developed severe zinc deficiency. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Two different maternal variants were linked to profoundly low milk zinc. organism: Homo sapiens tissue_or_cell_type: Maternal milk and breastfed infant experimental_model: Human mother–infant clinical genetic observations limitations: Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background. exposure: Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting. cross_nutrient: Maternal zinc secretion determines a source of infant zinc supply. evidence_span: {"source_cache": "artifacts/zinc-transport-sources/23741301-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "b422d27e8731293ae1597e65a72d9a6f6c1a161b7adaff3f114ee23f0e95408a"} [zinc-trans-23741301] Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. (2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045
Complete structured claim and evidenceIn the reported family, two exclusively breastfed infants developed zinc deficiency associated with low maternal milk zinc; affected mothers carried SLC30A2 H54R.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Maternal zinc secretion determines a source of infant zinc supply.
- evidence_span
- {"source_cache": "artifacts/zinc-transport-sources/17065149-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "a10d24cc13794e7cda0ab3553fa7b351c4f2faa583c78331b96f96edfacbe9d1"}
- experimental_model
- Human mother–infant clinical genetic observations
- exposure
- Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting.
- limitations
- Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- A maternal transport variant was linked to low milk zinc and infant deficiency.
- primary_references
- [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
- tissue_or_cell_type
- Maternal milk and breastfed infant
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 557–569
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human mother–infant clinical genetic observations · source_derived_draft · unverified_draft
### zinc-trans-milk-h54r-family In the reported family, two exclusively breastfed infants developed zinc deficiency associated with low maternal milk zinc; affected mothers carried SLC30A2 H54R. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A maternal transport variant was linked to low milk zinc and infant deficiency. organism: Homo sapiens tissue_or_cell_type: Maternal milk and breastfed infant experimental_model: Human mother–infant clinical genetic observations limitations: Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background. exposure: Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting. cross_nutrient: Maternal zinc secretion determines a source of infant zinc supply. evidence_span: {"source_cache": "artifacts/zinc-transport-sources/17065149-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "a10d24cc13794e7cda0ab3553fa7b351c4f2faa583c78331b96f96edfacbe9d1"} [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.