Breast-milk zinc concentration: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

A mother carrying W152R and S296L on different SLC30A2 alleles had a reported greater-than-90% reduction in milk zinc; her breastfed infant developed severe zinc deficiency.
Human ZnT2 (SLC30A2) → Breast-milk zinc concentration source_derived_draftungraded
Experimental context and source evidence
availability_state
machinery_impairment Imported condition classification; unverified.
cross_nutrient
Maternal zinc secretion determines a source of infant zinc supply.
evidence_span
{"source_cache": "artifacts/zinc-transport-sources/23741301-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "b422d27e8731293ae1597e65a72d9a6f6c1a161b7adaff3f114ee23f0e95408a"}
experimental_model
Human mother–infant clinical genetic observations
exposure
Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting.
limitations
Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background.
nutrient_topic
Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
organism
Homo sapiens
plain_language
Two different maternal variants were linked to profoundly low milk zinc.
primary_references
[zinc-trans-23741301] Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. (2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045
tissue_or_cell_type
Maternal milk and breastfed infant
trigger_kind
machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 571–583
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human mother–infant clinical genetic observations · source_derived_draft · unverified_draft
### zinc-trans-milk-compound-variants A mother carrying W152R and S296L on different SLC30A2 alleles had a reported greater-than-90% reduction in milk zinc; her breastfed infant developed severe zinc deficiency. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Two different maternal variants were linked to profoundly low milk zinc. organism: Homo sapiens tissue_or_cell_type: Maternal milk and breastfed infant experimental_model: Human mother–infant clinical genetic observations limitations: Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background. exposure: Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting. cross_nutrient: Maternal zinc secretion determines a source of infant zinc supply. evidence_span: {"source_cache": "artifacts/zinc-transport-sources/23741301-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "b422d27e8731293ae1597e65a72d9a6f6c1a161b7adaff3f114ee23f0e95408a"} [zinc-trans-23741301] Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. (2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045
Complete structured claim and evidence
In the reported family, two exclusively breastfed infants developed zinc deficiency associated with low maternal milk zinc; affected mothers carried SLC30A2 H54R.
Human ZnT2 (SLC30A2) → Breast-milk zinc concentration source_derived_draftungraded
Experimental context and source evidence
availability_state
machinery_impairment Imported condition classification; unverified.
cross_nutrient
Maternal zinc secretion determines a source of infant zinc supply.
evidence_span
{"source_cache": "artifacts/zinc-transport-sources/17065149-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "a10d24cc13794e7cda0ab3553fa7b351c4f2faa583c78331b96f96edfacbe9d1"}
experimental_model
Human mother–infant clinical genetic observations
exposure
Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting.
limitations
Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background.
nutrient_topic
Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
organism
Homo sapiens
plain_language
A maternal transport variant was linked to low milk zinc and infant deficiency.
primary_references
[zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
tissue_or_cell_type
Maternal milk and breastfed infant
trigger_kind
machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 557–569
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human mother–infant clinical genetic observations · source_derived_draft · unverified_draft
### zinc-trans-milk-h54r-family In the reported family, two exclusively breastfed infants developed zinc deficiency associated with low maternal milk zinc; affected mothers carried SLC30A2 H54R. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A maternal transport variant was linked to low milk zinc and infant deficiency. organism: Homo sapiens tissue_or_cell_type: Maternal milk and breastfed infant experimental_model: Human mother–infant clinical genetic observations limitations: Small family/case evidence does not establish population frequency or penetrance. Molecular cell assays are separate linked claims; maternal supplementation response is not inferred for these individuals from introductory background. exposure: Naturally occurring maternal SLC30A2 variants; exclusive breastfeeding in the reported case setting. cross_nutrient: Maternal zinc secretion determines a source of infant zinc supply. evidence_span: {"source_cache": "artifacts/zinc-transport-sources/17065149-abstract.txt", "locator": "Primary indexed abstract; case results", "file_sha256": "a10d24cc13794e7cda0ab3553fa7b351c4f2faa583c78331b96f96edfacbe9d1"} [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Breast-milk zinc concentration