Component
Human nuclear receptor coactivator 4 / NCOA4
Human nuclear receptor coactivator 4 / NCOA4. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
NCOA4 associated with ferritin heavy/light chains and was required for their delivery to lysosomes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/24695223.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a", "start_char": 0, "end_char": 1514, "text_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a"}
- experimental_model
- Quantitative proteomics and selective-autophagy experiments
- exposure
- NCOA4 association and loss experiments
- limitations
- Ferritinophagy supplies intracellular iron; it is not equivalent to serum ferritin concentration.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Human cultured cells
- plain_language
- A selective cargo receptor sends stored iron for release when cells need it.
- primary_references
- [iron-p24695223] Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. (2014). https://pubmed.ncbi.nlm.nih.gov/24695223/ DOI: 10.1038/nature13148
- tissue_or_cell_type
- Autophagosomes and lysosomes
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 641–652
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Quantitative proteomics and selective-autophagy experiments · source_derived_draft · unverified_draft
### iron-ncoa4-ferritin NCOA4 associated with ferritin heavy/light chains and was required for their delivery to lysosomes. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A selective cargo receptor sends stored iron for release when cells need it. organism: Human cultured cells tissue_or_cell_type: Autophagosomes and lysosomes experimental_model: Quantitative proteomics and selective-autophagy experiments limitations: Ferritinophagy supplies intracellular iron; it is not equivalent to serum ferritin concentration. exposure: NCOA4 association and loss experiments evidence_span: {"source_cache": "artifacts/iron-research/24695223.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a", "start_char": 0, "end_char": 1514, "text_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a"} [iron-p24695223] Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. (2014). https://pubmed.ncbi.nlm.nih.gov/24695223/ DOI: 10.1038/nature13148
Complete structured claim and evidenceNCOA4-deficient cells could not degrade ferritin normally and had decreased bioavailable intracellular iron.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/24695223.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a", "start_char": 0, "end_char": 1514, "text_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a"}
- experimental_model
- Quantitative proteomics and selective-autophagy experiments
- exposure
- NCOA4 association and loss experiments
- limitations
- Ferritinophagy supplies intracellular iron; it is not equivalent to serum ferritin concentration.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Human cultured cells
- plain_language
- The cell could have iron in a storage cage while still lacking usable iron.
- primary_references
- [iron-p24695223] Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. (2014). https://pubmed.ncbi.nlm.nih.gov/24695223/ DOI: 10.1038/nature13148
- tissue_or_cell_type
- Autophagosomes and lysosomes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 654–665
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Quantitative proteomics and selective-autophagy experiments · source_derived_draft · unverified_draft
### iron-ncoa4-loss NCOA4-deficient cells could not degrade ferritin normally and had decreased bioavailable intracellular iron. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cell could have iron in a storage cage while still lacking usable iron. organism: Human cultured cells tissue_or_cell_type: Autophagosomes and lysosomes experimental_model: Quantitative proteomics and selective-autophagy experiments limitations: Ferritinophagy supplies intracellular iron; it is not equivalent to serum ferritin concentration. exposure: NCOA4 association and loss experiments evidence_span: {"source_cache": "artifacts/iron-research/24695223.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a", "start_char": 0, "end_char": 1514, "text_sha256": "ff28f2795755fe6ec56b532f23bfdb66f3925ed0403c86ade859971ec1cc303a"} [iron-p24695223] Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. (2014). https://pubmed.ncbi.nlm.nih.gov/24695223/ DOI: 10.1038/nature13148
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.