Component
Human NAPRT knockdown
Experimental reduction of human NAPRT expression.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
NAPRT knockdown reversed the rise in cellular NAD caused by nicotinic acid in the cultured human cells studied.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/niacin-precursors-sources/hara2007.abstract.txt", "locator": "Indexed primary abstract", "start_char": 0, "end_char": 1634, "file_sha256": "4a605e0551bc9453dec63e8aa1e0fcd78985ae7dfca8d4b785039de0e0382547", "text_sha256": "4a605e0551bc9453dec63e8aa1e0fcd78985ae7dfca8d4b785039de0e0382547"}
- experimental_model
- Cultured human cells with endogenous NAPRT and experimental NAPRT knockdown; separate mouse expression measurements
- exposure
- NAPRT knockdown plus nicotinic acid; concentration and duration not independently available in indexed abstract
- limitations
- The abstract does not specify the cell line or dosing details; no inference to oral intake or patient response.
- nutrient_topic
- Niacin research collection; topical membership is not evidence of a direct dietary effect. · Niacin (vitamin B3)
- organism
- Homo sapiens
- plain_language
- Nicotinic acid could not produce the same NAD rise after its entry enzyme was suppressed.
- primary_references
- [b3-pre-hara2007] Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. (2007). https://pubmed.ncbi.nlm.nih.gov/17604275/ DOI: 10.1074/jbc.m610357200
- tissue_or_cell_type
- Cultured human cells expressing endogenous NAPRT
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Niacin: NAD metabolism, deficiency and nutrient interactions (2026-09-17) · lines 289–300
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cultured human cells with endogenous NAPRT and experimental NAPRT knockdown; separate mouse expression measurements · source_derived_draft · unverified_draft
### b3-pre-naprt-knockdown-na NAPRT knockdown reversed the rise in cellular NAD caused by nicotinic acid in the cultured human cells studied. Condition category: machinery_impairment nutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Nicotinic acid could not produce the same NAD rise after its entry enzyme was suppressed. organism: Homo sapiens tissue_or_cell_type: Cultured human cells expressing endogenous NAPRT experimental_model: Cultured human cells with endogenous NAPRT and experimental NAPRT knockdown; separate mouse expression measurements limitations: The abstract does not specify the cell line or dosing details; no inference to oral intake or patient response. exposure: NAPRT knockdown plus nicotinic acid; concentration and duration not independently available in indexed abstract evidence_span: {"source_cache": "artifacts/niacin-precursors-sources/hara2007.abstract.txt", "locator": "Indexed primary abstract", "start_char": 0, "end_char": 1634, "file_sha256": "4a605e0551bc9453dec63e8aa1e0fcd78985ae7dfca8d4b785039de0e0382547", "text_sha256": "4a605e0551bc9453dec63e8aa1e0fcd78985ae7dfca8d4b785039de0e0382547"} [b3-pre-hara2007] Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. (2007). https://pubmed.ncbi.nlm.nih.gov/17604275/ DOI: 10.1074/jbc.m610357200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.