Component
N-retinylidene-phosphatidylethanolamine
Schiff-base adduct of retinal and phosphatidylethanolamine; isomer specified in claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
ABCA4 drove ATP-dependent transport of retinal-PE adduct from the disc lumen-facing leaflet toward the cytoplasmic leaflet.
Experimental context and source evidence
- experimental_model
- Proteoliposomes and native disc transport assays
- limitations
- The assayed substrate is the adduct, not a requirement for free retinal diffusion.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Bovine/mouse discs; recombinant transporter
- plain_language
- ABCA4 moves the trapped retinal-lipid adduct to the disposal side of the disc.
- primary_references
- [quazi-2012] ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3871175/ DOI: 10.1038/ncomms1927
- tissue_or_cell_type
- Photoreceptor disc membrane
- transport_direction
- disc lumen leaflet to cytoplasmic leaflet
- transport_effect
- raises Recorded as ATP-dependent transport from the disc lumen-facing leaflet toward the cytoplasmic leaflet.
- transport_pool
- the cytoplasmic leaflet of the disc membrane Recorded as ATP-dependent transport from the disc lumen-facing leaflet toward the cytoplasmic leaflet.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 801–811
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Proteoliposomes and native disc transport assays · source_derived_draft · unverified_draft
### a-vision-abca4-retinoid-flip ABCA4 drove ATP-dependent transport of retinal-PE adduct from the disc lumen-facing leaflet toward the cytoplasmic leaflet. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: ABCA4 moves the trapped retinal-lipid adduct to the disposal side of the disc. organism: Bovine/mouse discs; recombinant transporter tissue_or_cell_type: Photoreceptor disc membrane experimental_model: Proteoliposomes and native disc transport assays limitations: The assayed substrate is the adduct, not a requirement for free retinal diffusion. transport_direction: disc lumen leaflet to cytoplasmic leaflet [quazi-2012] ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer (2012). https://pmc.ncbi.nlm.nih.gov/articles/PMC3871175/ DOI: 10.1038/ncomms1927
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.