Component
N-Acetylaspartylglutamate / NAAG
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Coexpressing mouse Nat8l and Rimklb in CHO-K1 or HEK293T cells enabled NAAG production from the NAA-synthesis pathway.
Experimental context and source evidence
- evidence_access
- Primary abstract and primary methods/figure text
- experimental_model
- Mouse-brain cDNA constructs in hamster/human cell hosts; product identified by HPLC and tandem mass spectrometry.
- limitations
- Host-cell species is not the enzyme species; no dietary brain-delivery effect was tested.
- nutrient_topic
- L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Aspartate
- plain_language
- Aspartate-derived NAA can feed a second, glutamate-containing product.
- primary_references
- Molecular characterization of N-acetylaspartylglutamate synthetase. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20643647/ · DOI 10.1074/jbc.M110.111765
L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19) · lines 370–376
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse-brain cDNA constructs in hamster/human cell hosts; product identified by HPLC and tandem mass spectrometry. · source_derived_draft · unverified_draft
## l-aspartate-naa-naag-supply Aspartate-derived NAA can feed a second, glutamate-containing product. Coexpressing mouse Nat8l and Rimklb in CHO-K1 or HEK293T cells enabled NAAG production from the NAA-synthesis pathway. Model: Mouse-brain cDNA constructs in hamster/human cell hosts; product identified by HPLC and tandem mass spectrometry. Limitations: Host-cell species is not the enzyme species; no dietary brain-delivery effect was tested. Evidence access: Primary abstract and primary methods/figure text Molecular characterization of N-acetylaspartylglutamate synthetase. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20643647/ · DOI 10.1074/jbc.M110.111765
Complete structured claim and evidenceCoexpression of the mouse NaDC3 transporter with Rimklb enabled supplied NAA to support NAAG synthesis in heterologous cells.
Experimental context and source evidence
- evidence_access
- Primary abstract and primary methods/figure text
- experimental_model
- Mouse transporter/enzyme cDNAs; CHO-K1 and HEK293T cell experiments.
- limitations
- This is NAA transport, not proof that NaDC3 transports free L-aspartate in the tested assay.
- nutrient_topic
- L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Aspartate
- plain_language
- Transport of the intermediate can gate the next synthesis step.
- primary_references
- Molecular characterization of N-acetylaspartylglutamate synthetase. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20643647/ · DOI 10.1074/jbc.M110.111765
L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19) · lines 378–384
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse transporter/enzyme cDNAs; CHO-K1 and HEK293T cell experiments. · source_derived_draft · unverified_draft
## l-aspartate-naag-import-route Transport of the intermediate can gate the next synthesis step. Coexpression of the mouse NaDC3 transporter with Rimklb enabled supplied NAA to support NAAG synthesis in heterologous cells. Model: Mouse transporter/enzyme cDNAs; CHO-K1 and HEK293T cell experiments. Limitations: This is NAA transport, not proof that NaDC3 transports free L-aspartate in the tested assay. Evidence access: Primary abstract and primary methods/figure text Molecular characterization of N-acetylaspartylglutamate synthetase. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20643647/ · DOI 10.1074/jbc.M110.111765
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.