Component
Tissue myo-inositol:D-chiro-inositol ratio
Tissue myo-inositol:D-chiro-inositol ratio. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
PCOS theca cells had increased epimerase activity and a lower myo-inositol:D-chiro-inositol ratio than control theca cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/inositol-research/24189751.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "908458aee805858d7e4d050e42256d81a0010564d86afe89d6a04656e856f219", "start_char": 0, "end_char": 1243, "text_sha256": "908458aee805858d7e4d050e42256d81a0010564d86afe89d6a04656e856f219"}
- experimental_model
- Cultured human ovarian theca-cell comparison
- exposure
- PCOS versus control-derived cells
- limitations
- Opposite direction to insulin-resistant peripheral tissues is tissue/context dependence, not a universal contradiction or proof of an optimal supplement ratio.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Homo sapiens
- plain_language
- The ovarian cell pattern differed from insulin-resistant peripheral tissues.
- primary_references
- [ino-p24189751] Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. (2014). https://pubmed.ncbi.nlm.nih.gov/24189751/ DOI: 10.1507/endocrj.ej13-0423
- tissue_or_cell_type
- Ovarian theca cells
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1211–1222
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cultured human ovarian theca-cell comparison · source_derived_draft · unverified_draft
### ino-theca-epimerase PCOS theca cells had increased epimerase activity and a lower myo-inositol:D-chiro-inositol ratio than control theca cells. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The ovarian cell pattern differed from insulin-resistant peripheral tissues. organism: Homo sapiens tissue_or_cell_type: Ovarian theca cells experimental_model: Cultured human ovarian theca-cell comparison limitations: Opposite direction to insulin-resistant peripheral tissues is tissue/context dependence, not a universal contradiction or proof of an optimal supplement ratio. exposure: PCOS versus control-derived cells evidence_span: {"source_cache": "artifacts/inositol-research/24189751.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "908458aee805858d7e4d050e42256d81a0010564d86afe89d6a04656e856f219", "start_char": 0, "end_char": 1243, "text_sha256": "908458aee805858d7e4d050e42256d81a0010564d86afe89d6a04656e856f219"} [ino-p24189751] Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. (2014). https://pubmed.ncbi.nlm.nih.gov/24189751/ DOI: 10.1507/endocrj.ej13-0423
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.