Component
Mouse vitamin K epoxide reductase / Vkorc1
Mouse vitamin K epoxide reductase / Vkorc1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Vkorc1-null mice died 2–20 days after birth with severe deficiency of carboxylated clotting factors and extensive hemorrhage.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/k2-research/19492146.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f3957681861ebb8860b46b4a29e6b9c142ba79e7abff1af925dd48b7f0e0c6c", "start_char": 0, "end_char": 1237, "text_sha256": "4f3957681861ebb8860b46b4a29e6b9c142ba79e7abff1af925dd48b7f0e0c6c"}
- experimental_model
- Knockout and oral vitamin K rescue
- exposure
- Vkorc1 deletion
- limitations
- Shared vitamin K pathway; the rescue is not proof that K2 supplements replace medical management. Later alternative reductase findings prevent treating the paper as evidence that no bypass can exist.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Mice
- plain_language
- A major failure in the shared vitamin K cycle can become a clotting failure.
- primary_references
- [k2-p19492146] VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding. (2009). https://pubmed.ncbi.nlm.nih.gov/19492146/ DOI: 10.1160/th09-03-0204
- tissue_or_cell_type
- Postnatal coagulation and skeletal development
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 903–914
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Knockout and oral vitamin K rescue · source_derived_draft · unverified_draft
### k2-vkor-bleeding Vkorc1-null mice died 2–20 days after birth with severe deficiency of carboxylated clotting factors and extensive hemorrhage. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A major failure in the shared vitamin K cycle can become a clotting failure. organism: Mice tissue_or_cell_type: Postnatal coagulation and skeletal development experimental_model: Knockout and oral vitamin K rescue limitations: Shared vitamin K pathway; the rescue is not proof that K2 supplements replace medical management. Later alternative reductase findings prevent treating the paper as evidence that no bypass can exist. exposure: Vkorc1 deletion evidence_span: {"source_cache": "artifacts/k2-research/19492146.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f3957681861ebb8860b46b4a29e6b9c142ba79e7abff1af925dd48b7f0e0c6c", "start_char": 0, "end_char": 1237, "text_sha256": "4f3957681861ebb8860b46b4a29e6b9c142ba79e7abff1af925dd48b7f0e0c6c"} [k2-p19492146] VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding. (2009). https://pubmed.ncbi.nlm.nih.gov/19492146/ DOI: 10.1160/th09-03-0204
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.