Component
Keratinocyte-targeted ligand-binding-defective VDR transgene
Study-defined Keratinocyte-targeted ligand-binding-defective VDR transgene. Read each linked record for species, exposure and endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Keratinocyte-targeted ligand-binding-defective VDR restored normal hair cycling in VDR-null mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays
- exposure
- Keratinocyte-specific mutant VDR transgenes in VDR-null mice.
- limitations
- Engineered mouse VDR system; does not establish a vitamin D supplement as treatment for human hair loss.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Mus musculus
- plain_language
- A receptor defect and a vitamin shortage are different problems.
- primary_references
- [skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415
- tissue_or_cell_type
- Keratinocytes/hair follicles
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1184–1195
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays · source_derived_draft · unverified_draft
### vd-hair-binding Keratinocyte-targeted ligand-binding-defective VDR restored normal hair cycling in VDR-null mice. Condition category: machinery_impairment nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A receptor defect and a vitamin shortage are different problems. organism: Mus musculus tissue_or_cell_type: Keratinocytes/hair follicles experimental_model: Keratinocyte-targeted mutant VDR transgenes in VDR-null mice; binding/repression assays limitations: Engineered mouse VDR system; does not establish a vitamin D supplement as treatment for human hair loss. exposure: Keratinocyte-specific mutant VDR transgenes in VDR-null mice. cross_nutrient: false [skorija2005] Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. (2005). https://pubmed.ncbi.nlm.nih.gov/15591533/ DOI: 10.1210/me.2004-0415
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.