Component
Mouse tight-junction protein ZO-1 / Tjp1
Mouse tight-junction protein ZO-1 / Tjp1
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
RA pretreatment mitigated loss of ZO-1 expression during the E. coli challenge.
Experimental context and source evidence
- evidence_access
- Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
- experimental_contrast
- {"intervention": "RA pretreatment plus bacterial challenge", "comparator": "Bacterial challenge alone", "endpoint": "RA pretreatment mitigated loss of ZO-1 expression during the E. coli challenge.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
- experimental_model
- Mice: oral 20 mg/kg for one week before intraperitoneal challenge; accompanying mouse epithelial-cell experiments.
- interpretation_status
- Recorded from source with stated access limits; ungraded, not independent replication.
- limitations
- Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
- nutrient_topic
- Rosmarinic acid collection; exact intervention and molecular form govern interpretation. · Rosmarinic acid
- plain_language
- RA pretreatment mitigated loss of ZO-1 expression during the E. coli challenge.
- primary_references
- Rosmarinic acid alleviated intestinal barrier damage caused by <i>Escherichia coli</i> by regulating the gut microbiota and inhibiting the NF-κB signalling pathway in mice. | https://pubmed.ncbi.nlm.nih.gov/39540591/ | https://doi.org/10.1039/d4fo02654c
- source_locator
- Reviewed reference ra-mouse-zo1; The abstract has contradictory permeability wording, so no quantitative permeability claim is assigned.
Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026) · lines 546–552
AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Mice: oral 20 mg/kg for one week before intraperitoneal challenge; accompanying mouse epithelial-cell experiments. · Recorded from source · Recorded from source
### ra-mouse-zo1 RA pretreatment mitigated loss of ZO-1 expression during the E. coli challenge. The abstract has contradictory permeability wording, so no quantitative permeability claim is assigned. Model and exposure: Mice: oral 20 mg/kg for one week before intraperitoneal challenge; accompanying mouse epithelial-cell experiments. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Rosmarinic acid alleviated intestinal barrier damage caused by <i>Escherichia coli</i> by regulating the gut microbiota and inhibiting the NF-κB signalling pathway in mice. | 2024 | https://pubmed.ncbi.nlm.nih.gov/39540591/ | https://doi.org/10.1039/d4fo02654c | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.