Component
TBK1 palmitoylation in mouse cells
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
LYPLA2 knockout prevented the reported stimulus-associated decline in TBK1 palmitoylation.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Mouse RAW 264.7; wild-type versus Lypla2 knockout
- exposure
- Plasmodium gDNA stimulation for 12 hours; concentration unresolved in this extraction.
- limitations
- Positive denotes preservation relative to stimulated wild-type, not an unqualified increase above resting baseline. No GPX4 endpoint.
- organism
- Mouse
- primary_locator
- Figure 3c; ABE and immunoblot.
- primary_references
- https://doi.org/10.1038/s41467-025-65081-8
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
MAVS inhibitor nulls and APT2-TBK1 immune feedback · lines 78–84
Selected primary observations: 10.1073/pnas.2403392121; 10.1038/s41467-025-65081-8. · supports · Mouse RAW 264.7; wild-type versus Lypla2 knockout · source_derived_draft · unverified_draft
LYPLA2 knockout prevented the reported stimulus-associated decline in TBK1 palmitoylation. primary_references: https://doi.org/10.1038/s41467-025-65081-8 primary_locator: Figure 3c; ABE and immunoblot. organism: Mouse experimental_model: Mouse RAW 264.7; wild-type versus Lypla2 knockout exposure: Plasmodium gDNA stimulation for 12 hours; concentration unresolved in this extraction. limitations: Positive denotes preservation relative to stimulated wild-type, not an unqualified increase above resting baseline. No GPX4 endpoint.
Complete structured claim and evidenceML349 increased TBK1 palmitoylation in mouse peritoneal macrophages.
Experimental context and source evidence
- experimental_model
- Mouse peritoneal exudate macrophages
- exposure
- ML349 concentration series for 12 hours; individual concentrations not transcribed from figure.
- limitations
- Concentration-response result; ABE is an S-acylation assay. No GPX4 endpoint in this experiment.
- organism
- Mouse
- primary_locator
- Figure 3b; ABE and immunoblot.
- primary_references
- https://doi.org/10.1038/s41467-025-65081-8
MAVS inhibitor nulls and APT2-TBK1 immune feedback · lines 69–75
Selected primary observations: 10.1073/pnas.2403392121; 10.1038/s41467-025-65081-8. · supports · Mouse peritoneal exudate macrophages · source_derived_draft · unverified_draft
ML349 increased TBK1 palmitoylation in mouse peritoneal macrophages. primary_references: https://doi.org/10.1038/s41467-025-65081-8 primary_locator: Figure 3b; ABE and immunoblot. organism: Mouse experimental_model: Mouse peritoneal exudate macrophages exposure: ML349 concentration series for 12 hours; individual concentrations not transcribed from figure. limitations: Concentration-response result; ABE is an S-acylation assay. No GPX4 endpoint in this experiment.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.