Component
Mouse metalloreductase Steap4
Mouse metalloreductase Steap4. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Expressed mouse Steap4 reduced Cu(II) to Cu(I) and increased cellular copper uptake in the tested human cell system.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/16609065.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f", "start_char": 0, "end_char": 827, "text_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f"}
- experimental_model
- Mouse Steap expression constructs and metal-reduction assays
- exposure
- Transient expression of Steap2, Steap3 or Steap4
- limitations
- Protein species verified in primary Methods (PMC1785011). Overexpression does not establish the dominant intestinal reductase in humans; relative activity can reflect localization and abundance.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Mouse proteins expressed in human HEK293T cells
- plain_language
- This enzyme prepares copper in a chemical form compatible with uptake.
- primary_references
- [copper-p16609065] The Steap proteins are metalloreductases. (2006). https://pubmed.ncbi.nlm.nih.gov/16609065/ DOI: 10.1182/blood-2006-02-003681
- tissue_or_cell_type
- Cell surface and endosomal compartments
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 299–310
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse Steap expression constructs and metal-reduction assays · source_derived_draft · unverified_draft
### copper-steap4-reduces-copper Expressed mouse Steap4 reduced Cu(II) to Cu(I) and increased cellular copper uptake in the tested human cell system. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: This enzyme prepares copper in a chemical form compatible with uptake. organism: Mouse proteins expressed in human HEK293T cells tissue_or_cell_type: Cell surface and endosomal compartments experimental_model: Mouse Steap expression constructs and metal-reduction assays limitations: Protein species verified in primary Methods (PMC1785011). Overexpression does not establish the dominant intestinal reductase in humans; relative activity can reflect localization and abundance. exposure: Transient expression of Steap2, Steap3 or Steap4 evidence_span: {"source_cache": "artifacts/copper-research/16609065.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f", "start_char": 0, "end_char": 827, "text_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f"} [copper-p16609065] The Steap proteins are metalloreductases. (2006). https://pubmed.ncbi.nlm.nih.gov/16609065/ DOI: 10.1182/blood-2006-02-003681
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.