Component

Mouse metalloreductase Steap3

Mouse metalloreductase Steap3. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Expressed mouse Steap3 reduced Cu(II) to Cu(I) and increased cellular copper uptake in the tested human cell system.

    Mouse metalloreductase Steap3 → Copper(II) ion source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/copper-research/16609065.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f", "start_char": 0, "end_char": 827, "text_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f"}
    experimental_model
    Mouse Steap expression constructs and metal-reduction assays
    exposure
    Transient expression of Steap2, Steap3 or Steap4
    limitations
    Protein species verified in primary Methods (PMC1785011). Overexpression does not establish the dominant intestinal reductase in humans; relative activity can reflect localization and abundance.
    nutrient_topic
    Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
    organism
    Mouse proteins expressed in human HEK293T cells
    plain_language
    This enzyme prepares copper in a chemical form compatible with uptake.
    primary_references
    [copper-p16609065] The Steap proteins are metalloreductases. (2006). https://pubmed.ncbi.nlm.nih.gov/16609065/ DOI: 10.1182/blood-2006-02-003681
    tissue_or_cell_type
    Cell surface and endosomal compartments

    Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 286–297

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse Steap expression constructs and metal-reduction assays · source_derived_draft · unverified_draft

    ### copper-steap3-reduces-copper Expressed mouse Steap3 reduced Cu(II) to Cu(I) and increased cellular copper uptake in the tested human cell system. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: This enzyme prepares copper in a chemical form compatible with uptake. organism: Mouse proteins expressed in human HEK293T cells tissue_or_cell_type: Cell surface and endosomal compartments experimental_model: Mouse Steap expression constructs and metal-reduction assays limitations: Protein species verified in primary Methods (PMC1785011). Overexpression does not establish the dominant intestinal reductase in humans; relative activity can reflect localization and abundance. exposure: Transient expression of Steap2, Steap3 or Steap4 evidence_span: {"source_cache": "artifacts/copper-research/16609065.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f", "start_char": 0, "end_char": 827, "text_sha256": "d0f42a3f30c22ba4235d82f21ba165c78b6c519a6218f487411fb2247ecc0d9f"} [copper-p16609065] The Steap proteins are metalloreductases. (2006). https://pubmed.ncbi.nlm.nih.gov/16609065/ DOI: 10.1182/blood-2006-02-003681
    Complete structured claim and evidence

  2. Steap3 colocalized with transferrin-cycle endosomes and promoted iron reduction and transferrin-dependent iron uptake.

    Mouse metalloreductase Steap3 → Transferrin-dependent endosomal iron delivery to cytosol source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/16227996.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd6e35b6ea534163d0db76cbdec2fa6c3c2dd998b0a1f66d9f16479bcb87711b", "start_char": 0, "end_char": 1006, "text_sha256": "cd6e35b6ea534163d0db76cbdec2fa6c3c2dd998b0a1f66d9f16479bcb87711b"}
    experimental_model
    Positional cloning, overexpression and deficient-mouse experiments
    exposure
    Steap3 deficiency and overexpression
    limitations
    A dominant erythroid reduction pathway, not proof of equal dependence in every tissue.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Mice and mouse Steap3 expression systems
    plain_language
    Iron released from transferrin needs another chemical reduction step before it can leave the endosome.
    primary_references
    [iron-p16227996] Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. (2005). https://pubmed.ncbi.nlm.nih.gov/16227996/ DOI: 10.1038/ng1658
    tissue_or_cell_type
    Erythroid endosomes

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 446–457

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Positional cloning, overexpression and deficient-mouse experiments · source_derived_draft · unverified_draft

    ### iron-steap-reduction Steap3 colocalized with transferrin-cycle endosomes and promoted iron reduction and transferrin-dependent iron uptake. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron released from transferrin needs another chemical reduction step before it can leave the endosome. organism: Mice and mouse Steap3 expression systems tissue_or_cell_type: Erythroid endosomes experimental_model: Positional cloning, overexpression and deficient-mouse experiments limitations: A dominant erythroid reduction pathway, not proof of equal dependence in every tissue. exposure: Steap3 deficiency and overexpression evidence_span: {"source_cache": "artifacts/iron-research/16227996.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cd6e35b6ea534163d0db76cbdec2fa6c3c2dd998b0a1f66d9f16479bcb87711b", "start_char": 0, "end_char": 1006, "text_sha256": "cd6e35b6ea534163d0db76cbdec2fa6c3c2dd998b0a1f66d9f16479bcb87711b"} [iron-p16227996] Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. (2005). https://pubmed.ncbi.nlm.nih.gov/16227996/ DOI: 10.1038/ng1658
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards