Component
Mouse Slc44a4 thiamine diphosphate transporter
Mouse colonic transporter; kept distinct from human SLC44A4.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Slc44a4-null mice were more susceptible to experimental DSS colitis than wild-type littermates.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence-scope
- Colon
- evidence_locator
- Abstract
- evidence_spans
- [{"source_document": "artifacts/thiamine_transport_sources/sabui-2024-slc44a4-knockout-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 2031}]
- experimental_model
- Cre-Lox Slc44a4 knockout mice versus littermates; uptake and DSS challenge.
- limitations
- No isolated proof that ThDP depletion mediates the entire inflammatory effect.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Mus musculus
- plain_language
- Losing the colonic carrier worsened the response to an inflammatory challenge.
- primary_references
- [sabui-2024-slc44a4-knockout] Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology (2024). https://pubmed.ncbi.nlm.nih.gov/38713615/ DOI: 10.1152/ajpgi.00065.2024
- tissue_or_cell_type
- Colon
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 574–586
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cre-Lox Slc44a4 knockout mice versus littermates; uptake and DSS challenge. · source_derived_draft · unverified_draft
### b1-slc44a4-mouse-dss-susceptibility Slc44a4-null mice were more susceptible to experimental DSS colitis than wild-type littermates. Condition category: machinery_impairment nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Losing the colonic carrier worsened the response to an inflammatory challenge. organism: Mus musculus tissue_or_cell_type: Colon experimental_model: Cre-Lox Slc44a4 knockout mice versus littermates; uptake and DSS challenge. limitations: No isolated proof that ThDP depletion mediates the entire inflammatory effect. evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/sabui-2024-slc44a4-knockout-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 2031}] evidence_locator: Abstract evidence-scope: Colon [sabui-2024-slc44a4-knockout] Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology (2024). https://pubmed.ncbi.nlm.nih.gov/38713615/ DOI: 10.1152/ajpgi.00065.2024
Complete structured claim and evidenceSlc44a4 knockout nearly eliminated carrier-mediated colonic radiolabeled-ThDP uptake in mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence-scope
- Colon
- evidence_locator
- Abstract
- evidence_spans
- [{"source_document": "artifacts/thiamine_transport_sources/sabui-2024-slc44a4-knockout-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 2031}]
- experimental_model
- Cre-Lox Slc44a4 knockout mice versus littermates; uptake and DSS challenge.
- limitations
- Does not quantify human systemic B1 supply.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Mus musculus
- plain_language
- The carrier accounts for most measured colonic uptake in this model.
- primary_references
- [sabui-2024-slc44a4-knockout] Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology (2024). https://pubmed.ncbi.nlm.nih.gov/38713615/ DOI: 10.1152/ajpgi.00065.2024
- tissue_or_cell_type
- Colon
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 560–572
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cre-Lox Slc44a4 knockout mice versus littermates; uptake and DSS challenge. · source_derived_draft · unverified_draft
### b1-slc44a4-mouse-uptake-loss Slc44a4 knockout nearly eliminated carrier-mediated colonic radiolabeled-ThDP uptake in mice. Condition category: machinery_impairment nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The carrier accounts for most measured colonic uptake in this model. organism: Mus musculus tissue_or_cell_type: Colon experimental_model: Cre-Lox Slc44a4 knockout mice versus littermates; uptake and DSS challenge. limitations: Does not quantify human systemic B1 supply. evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/sabui-2024-slc44a4-knockout-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 2031}] evidence_locator: Abstract evidence-scope: Colon [sabui-2024-slc44a4-knockout] Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology (2024). https://pubmed.ncbi.nlm.nih.gov/38713615/ DOI: 10.1152/ajpgi.00065.2024
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.