Component

Serine-dependent expansion of activated mouse T cells

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Extracellular serine supported optimal activated T-cell expansion by providing glycine and one-carbon units for nucleotide biosynthesis; adequate glucose alone did not substitute.

    L-Serine → Serine-dependent expansion of activated mouse T cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary study of activated T cells with in-vivo pathogen-driven expansion experiments in mice.
    limitations
    Species and activation context limit translation to human supplementation. Correction record: PubMed indexes a published erratum, PMID 28178570 / DOI 10.1016/j.cmet.2017.01.014. The notice body was not accessible during this curation, so its specific scope and impact remain unverified. Do not treat the original study as having received comprehensive integrity clearance. https://pubmed.ncbi.nlm.nih.gov/28178570/
    nutrient_topic
    L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Serine
    plain_language
    Fuel availability alone does not meet every requirement for immune-cell division.
    primary_references
    Serine Is an Essential Metabolite for Effector T Cell Expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28111214/ · DOI 10.1016/j.cmet.2016.12.011

    L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19) · lines 214–220

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary study of activated T cells with in-vivo pathogen-driven expansion experiments in mice. · source_derived_draft · unverified_draft

    ## l-serine-tcell-expansion Fuel availability alone does not meet every requirement for immune-cell division. Extracellular serine supported optimal activated T-cell expansion by providing glycine and one-carbon units for nucleotide biosynthesis; adequate glucose alone did not substitute. Model: Primary study of activated T cells with in-vivo pathogen-driven expansion experiments in mice. Limitations: Species and activation context limit translation to human supplementation. Correction record: PubMed indexes a published erratum, PMID 28178570 / DOI 10.1016/j.cmet.2017.01.014. The notice body was not accessible during this curation, so its specific scope and impact remain unverified. Do not treat the original study as having received comprehensive integrity clearance. https://pubmed.ncbi.nlm.nih.gov/28178570/ Evidence access: Primary abstract Serine Is an Essential Metabolite for Effector T Cell Expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28111214/ · DOI 10.1016/j.cmet.2016.12.011
    Complete structured claim and evidence

  2. Dietary serine restriction impaired pathogen-driven T-cell expansion in the mouse experiments without disrupting overall immune-cell homeostasis; formate rescued serine-deprived T cells in culture.

    L-Serine → Serine-dependent expansion of activated mouse T cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Mouse dietary restriction and separate activated-cell formate add-back.
    limitations
    The culture rescue is not an in-vivo dietary rescue or a human treatment dose. Correction record: PubMed indexes a published erratum, PMID 28178570 / DOI 10.1016/j.cmet.2017.01.014. The notice body was not accessible during this curation, so its specific scope and impact remain unverified. Do not treat the original study as having received comprehensive integrity clearance. https://pubmed.ncbi.nlm.nih.gov/28178570/
    nutrient_topic
    L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Serine
    plain_language
    Shortage can impair an induced response without eliminating resting immune cells.
    primary_references
    Serine Is an Essential Metabolite for Effector T Cell Expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28111214/ · DOI 10.1016/j.cmet.2016.12.011
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19) · lines 222–228

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse dietary restriction and separate activated-cell formate add-back. · source_derived_draft · unverified_draft

    ## l-serine-tcell-restriction Shortage can impair an induced response without eliminating resting immune cells. Dietary serine restriction impaired pathogen-driven T-cell expansion in the mouse experiments without disrupting overall immune-cell homeostasis; formate rescued serine-deprived T cells in culture. Model: Mouse dietary restriction and separate activated-cell formate add-back. Limitations: The culture rescue is not an in-vivo dietary rescue or a human treatment dose. Correction record: PubMed indexes a published erratum, PMID 28178570 / DOI 10.1016/j.cmet.2017.01.014. The notice body was not accessible during this curation, so its specific scope and impact remain unverified. Do not treat the original study as having received comprehensive integrity clearance. https://pubmed.ncbi.nlm.nih.gov/28178570/ Evidence access: Primary abstract Serine Is an Essential Metabolite for Effector T Cell Expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28111214/ · DOI 10.1016/j.cmet.2016.12.011
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards