Component
Mouse protein phosphatase 2A complex
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Lithium disrupted a beta-arrestin2–Akt–PP2A complex and altered Akt/GSK3 signaling in mice.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse pharmacology and biochemical complex assays.
- limitations
- A second pathway alongside direct enzyme inhibition, not a complete explanation of mood stabilization.
- nutrient_topic
- Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
- plain_language
- Lithium can change how signaling proteins assemble.
- primary_references
- A beta-arrestin 2 signaling complex mediates lithium action on behavior. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18191226/ · DOI 10.1016/j.cell.2007.11.041
Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 192–198
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse pharmacology and biochemical complex assays. · source_derived_draft · unverified_draft
## lithium-arrestin-complex Lithium can change how signaling proteins assemble. Lithium disrupted a beta-arrestin2–Akt–PP2A complex and altered Akt/GSK3 signaling in mice. Model: Mouse pharmacology and biochemical complex assays. Limitations: A second pathway alongside direct enzyme inhibition, not a complete explanation of mood stabilization. Evidence access: Primary abstract A beta-arrestin 2 signaling complex mediates lithium action on behavior. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18191226/ · DOI 10.1016/j.cell.2007.11.041
Complete structured claim and evidenceArrb2 knockout prevented the reported lithium effects on Akt/GSK3 signaling and associated mouse behaviors.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Mouse Arrb2 knockout comparison.
- limitations
- Does not abolish every molecular lithium effect.
- nutrient_topic
- Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
- plain_language
- Removing the scaffold removed this lithium response.
- primary_references
- A beta-arrestin 2 signaling complex mediates lithium action on behavior. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18191226/ · DOI 10.1016/j.cell.2007.11.041
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 200–206
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse Arrb2 knockout comparison. · source_derived_draft · unverified_draft
## lithium-arrestin-loss Removing the scaffold removed this lithium response. Arrb2 knockout prevented the reported lithium effects on Akt/GSK3 signaling and associated mouse behaviors. Model: Mouse Arrb2 knockout comparison. Limitations: Does not abolish every molecular lithium effect. Evidence access: Primary abstract A beta-arrestin 2 signaling complex mediates lithium action on behavior. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18191226/ · DOI 10.1016/j.cell.2007.11.041
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.