{"id":"f1a90370-1ed1-539e-ae75-5b2b5f6747d0","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-arrestin-complex","predicate":"disrupts","statement":"Lithium disrupted a beta-arrestin2–Akt–PP2A complex and altered Akt/GSK3 signaling in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ad81ea9e-f477-5271-a678-759be38aa494","mechanism_event_label":"Lithium can change how signaling proteins assemble.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"1beda181-8c53-5100-9eec-0a0b8ee89cdf","slug":"mouse-arrb2-akt-pp2a-signaling-complex","display_name":"Mouse beta-arrestin2–Akt–PP2A signaling complex","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ad81ea9e-f477-5271-a678-759be38aa494","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-arrestin-complex-event","event_type":"observed_relationship","label":"Lithium can change how signaling proteins assemble.","description":"Lithium disrupted a beta-arrestin2–Akt–PP2A complex and altered Akt/GSK3 signaling in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1beda181-8c53-5100-9eec-0a0b8ee89cdf","slug":"mouse-arrb2-akt-pp2a-signaling-complex","display_name":"Mouse beta-arrestin2–Akt–PP2A signaling complex","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fb2887f8-1193-57bc-add3-5b4677a8927e","slug":"mouse-arrb2","display_name":"Mouse beta-arrestin 2 / Arrb2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"a3704a1a-7721-52fe-9c28-f730cf86c0af","slug":"mouse-akt-signaling-pool","display_name":"Mouse Akt signaling pool","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"18ae6965-adac-5050-903c-9e155270d104","slug":"mouse-pp2a-complex","display_name":"Mouse protein phosphatase 2A complex","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"e7b85cc5-eead-5551-ba6d-40420edd8156","slug":"mouse-gsk3b","display_name":"Mouse glycogen synthase kinase 3 beta / Gsk3b","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse pharmacology and biochemical complex assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A second pathway alongside direct enzyme inhibition, not a complete explanation of mood stabilization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Lithium can change how signaling proteins assemble.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A beta-arrestin 2 signaling complex mediates lithium action on behavior. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18191226/ · DOI 10.1016/j.cell.2007.11.041","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"57318fda-7f5a-5dc9-a131-74c382ca4829","evidence_kind":"source_excerpt","locator":"Lines 192-198","start_line":192,"end_line":198,"excerpt":"## lithium-arrestin-complex\nLithium can change how signaling proteins assemble.\nLithium disrupted a beta-arrestin2–Akt–PP2A complex and altered Akt/GSK3 signaling in mice.\nModel: Mouse pharmacology and biochemical complex assays.\nLimitations: A second pathway alongside direct enzyme inhibition, not a complete explanation of mood stabilization.\nEvidence access: Primary abstract\nA beta-arrestin 2 signaling complex mediates lithium action on behavior. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18191226/ · DOI 10.1016/j.cell.2007.11.041","model_system":"Mouse pharmacology and biochemical complex assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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