Component
Mouse portal delivery of intact fructose
Species, exposure, manipulation and evidence limits are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At higher gavage doses, intestinal processing saturated and more intact fructose reached mouse portal blood and the liver.
Experimental context and source evidence
- dose
- 1:1 fructose/glucose gavage, typically 0.5 g/kg each; dose series 0.25-2 g/kg each
- duration
- Acute tracing; knockout portal AUC 0-30 min
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Male C57BL/6 mice, with Khk knockout comparisons
- exposure_scope
- Component mixture
- limitations
- Approximately 90% low-dose clearance is a mouse result, not an established human percentage. Fasting, feeding and prior exposure change clearance.
- nutrient_topic
- HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
- organism
- Male C57BL/6 mice, with Khk knockout comparisons
- plain_language
- At higher gavage doses, intestinal processing saturated and more intact fructose reached mouse portal blood and the liver.
- primary_references
- The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. (2018). https://pubmed.ncbi.nlm.nih.gov/29414685/ DOI: 10.1016/j.cmet.2017.12.016
- route
- Oral gavage with isotope tracers
- tissue
- Small intestine, portal blood and liver
High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 173–183
Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Male C57BL/6 mice, with Khk knockout comparisons · source_derived_draft · unverified_draft
## hfcs-intestinal-overflow At higher gavage doses, intestinal processing saturated and more intact fructose reached mouse portal blood and the liver. Model/species: Male C57BL/6 mice, with Khk knockout comparisons Tissue: Small intestine, portal blood and liver Exposure: 1:1 fructose/glucose gavage, typically 0.5 g/kg each; dose series 0.25-2 g/kg each Route: Oral gavage with isotope tracers Duration: Acute tracing; knockout portal AUC 0-30 min Exposure scope: Component mixture Limits: Approximately 90% low-dose clearance is a mouse result, not an established human percentage. Fasting, feeding and prior exposure change clearance. Reference: The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. (2018). https://pubmed.ncbi.nlm.nih.gov/29414685/ DOI: 10.1016/j.cmet.2017.12.016 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.