Component
Mouse peripheral-tissue ATP7A abundance
Mouse peripheral-tissue ATP7A abundance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Copper deficiency lowered ATP7A abundance in mouse peripheral tissues; subcutaneous copper restored it.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/28931909.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f", "start_char": 0, "end_char": 1284, "text_sha256": "040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f"}
- experimental_model
- Copper-deficient mouse models and subcutaneous copper administration
- exposure
- Systemic copper depletion and restoration
- limitations
- Opposite tissue responses are reported regulatory context, not a contradiction in the source.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Mouse
- plain_language
- Tissues adjusted their copper-export machinery as supply changed.
- primary_references
- [copper-p28931909] Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis. (2017). https://pubmed.ncbi.nlm.nih.gov/28931909/ DOI: 10.1038/s41598-017-11961-z
- tissue_or_cell_type
- Intestine, heart, spleen and liver
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 494–505
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Copper-deficient mouse models and subcutaneous copper administration · source_derived_draft · unverified_draft
### copper-atp7a-peripheral-response Copper deficiency lowered ATP7A abundance in mouse peripheral tissues; subcutaneous copper restored it. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Tissues adjusted their copper-export machinery as supply changed. organism: Mouse tissue_or_cell_type: Intestine, heart, spleen and liver experimental_model: Copper-deficient mouse models and subcutaneous copper administration limitations: Opposite tissue responses are reported regulatory context, not a contradiction in the source. exposure: Systemic copper depletion and restoration evidence_span: {"source_cache": "artifacts/copper-research/28931909.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f", "start_char": 0, "end_char": 1284, "text_sha256": "040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f"} [copper-p28931909] Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis. (2017). https://pubmed.ncbi.nlm.nih.gov/28931909/ DOI: 10.1038/s41598-017-11961-z
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.