Component
Mouse Pdxp pyridoxal phosphatase
Mus musculus Pdxp protein.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Ubiquitous Pdxp deletion raised PLP in brain, skeletal muscle and red cells by up to threefold compared with controls.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Indexed abstract: tissue PLP measurements
- experimental_model
- Conditional and ubiquitous Pdxp-deletion mice.
- exposure
- Genetic Pdxp ablation.
- limitations
- Effects vary by tissue; knockout does not model ordinary B6 intake.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Mus musculus
- plain_language
- Slower breakdown increased tissue PLP.
- primary_references
- [jeanclos2019] Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice. (2019). https://pubmed.ncbi.nlm.nih.gov/30327125/ DOI: 10.1016/j.bbadis.2018.08.018
- tissue_or_cell_type
- Brain, skeletal muscle and erythrocytes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 296–307
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional and ubiquitous Pdxp-deletion mice. · source_derived_draft · unverified_draft
### b6-transport-pdxp-mouse-pools Ubiquitous Pdxp deletion raised PLP in brain, skeletal muscle and red cells by up to threefold compared with controls. Condition category: machinery_impairment nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Slower breakdown increased tissue PLP. organism: Mus musculus tissue_or_cell_type: Brain, skeletal muscle and erythrocytes experimental_model: Conditional and ubiquitous Pdxp-deletion mice. limitations: Effects vary by tissue; knockout does not model ordinary B6 intake. exposure: Genetic Pdxp ablation. evidence_location: Indexed abstract: tissue PLP measurements [jeanclos2019] Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice. (2019). https://pubmed.ncbi.nlm.nih.gov/30327125/ DOI: 10.1016/j.bbadis.2018.08.018
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.