Component
Mouse iron accumulation across multiple organs
Mouse iron accumulation across multiple organs. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Whole-body double deletion loaded iron into duodenum, liver, heart and pancreas; intestine-specific Heph deletion with global Cp loss produced a more restricted distribution.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/30182051.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "57ed2ee0540cc9ec88748eaa23af1a38d307271d9e7ea6367a24d412622a4b72", "start_char": 0, "end_char": 1882, "text_sha256": "57ed2ee0540cc9ec88748eaa23af1a38d307271d9e7ea6367a24d412622a4b72"}
- experimental_model
- Whole-body and intestine-specific Heph/Cp double-knockout mice
- exposure
- Combined or tissue-specific deletion; oral iron tracer
- limitations
- Double knockouts differ from low dietary copper. Detectable iron absorption remained, so these enzymes are not an absolute all-or-none gate for every absorption route.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Mouse
- plain_language
- Where the enzyme is missing changes where iron gets trapped.
- primary_references
- [copper-p30182051] Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. (2018). https://pubmed.ncbi.nlm.nih.gov/30182051/ DOI: 10.1016/j.jcmgh.2018.06.006
- tissue_or_cell_type
- Intestine, liver, heart, pancreas and blood
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 832–843
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body and intestine-specific Heph/Cp double-knockout mice · source_derived_draft · unverified_draft
### copper-heph-cp-organ-loading Whole-body double deletion loaded iron into duodenum, liver, heart and pancreas; intestine-specific Heph deletion with global Cp loss produced a more restricted distribution. Condition category: machinery_impairment nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Where the enzyme is missing changes where iron gets trapped. organism: Mouse tissue_or_cell_type: Intestine, liver, heart, pancreas and blood experimental_model: Whole-body and intestine-specific Heph/Cp double-knockout mice limitations: Double knockouts differ from low dietary copper. Detectable iron absorption remained, so these enzymes are not an absolute all-or-none gate for every absorption route. exposure: Combined or tissue-specific deletion; oral iron tracer evidence_span: {"source_cache": "artifacts/copper-research/30182051.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "57ed2ee0540cc9ec88748eaa23af1a38d307271d9e7ea6367a24d412622a4b72", "start_char": 0, "end_char": 1882, "text_sha256": "57ed2ee0540cc9ec88748eaa23af1a38d307271d9e7ea6367a24d412622a4b72"} [copper-p30182051] Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. (2018). https://pubmed.ncbi.nlm.nih.gov/30182051/ DOI: 10.1016/j.jcmgh.2018.06.006
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.