Component
Mouse Mtarc1 p.Ala168Thr
Mouse Mtarc1 p.Ala168Thr. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
A168T mice had lower MTARC1 protein despite unchanged mRNA, but neither sex showed significant protection from steatosis, inflammation or fibrosis.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/molybdenum-research/41428769.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5ac3e4efcae2e5b23a255c61586bbff33d3114fe2c8e28befe2d9ad501f774bd", "start_char": 0, "end_char": 1816, "text_sha256": "5ac3e4efcae2e5b23a255c61586bbff33d3114fe2c8e28befe2d9ad501f774bd"}
- experimental_model
- Male/female mouse A168T knock-in in multiple MASH/fibrosis models
- exposure
- Mouse ortholog of human A165T; no global knockout
- limitations
- Partial variant effects are not identical to deleting the gene. No human molybdenum intervention.
- nutrient_topic
- Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
- organism
- Mus musculus
- plain_language
- Lower protein from this variant was not enough to reproduce knockout protection.
- primary_references
- [mo-p41428769] A mitochondrial amidoxime-reducing component 1 (mARC1) A168T amino acid substitution does not confer protection from MASH and fibrosis in multiple mouse models of chronic liver disease. (2026). https://pubmed.ncbi.nlm.nih.gov/41428769/ DOI: 10.1042/bcj20253411
- tissue_or_cell_type
- Liver disease and protein expression
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1587–1598
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Male/female mouse A168T knock-in in multiple MASH/fibrosis models · source_derived_draft · unverified_draft
### mo-marc-a168t-null A168T mice had lower MTARC1 protein despite unchanged mRNA, but neither sex showed significant protection from steatosis, inflammation or fibrosis. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lower protein from this variant was not enough to reproduce knockout protection. organism: Mus musculus tissue_or_cell_type: Liver disease and protein expression experimental_model: Male/female mouse A168T knock-in in multiple MASH/fibrosis models limitations: Partial variant effects are not identical to deleting the gene. No human molybdenum intervention. exposure: Mouse ortholog of human A165T; no global knockout evidence_span: {"source_cache": "artifacts/molybdenum-research/41428769.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5ac3e4efcae2e5b23a255c61586bbff33d3114fe2c8e28befe2d9ad501f774bd", "start_char": 0, "end_char": 1816, "text_sha256": "5ac3e4efcae2e5b23a255c61586bbff33d3114fe2c8e28befe2d9ad501f774bd"} [mo-p41428769] A mitochondrial amidoxime-reducing component 1 (mARC1) A168T amino acid substitution does not confer protection from MASH and fibrosis in multiple mouse models of chronic liver disease. (2026). https://pubmed.ncbi.nlm.nih.gov/41428769/ DOI: 10.1042/bcj20253411
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.