Component
Mouse matrix Gla protein / Mgp
Mouse matrix Gla protein / Mgp. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Mgp-null mice developed arterial calcification leading to vascular rupture and death within two months.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/k2-research/9052783.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97", "start_char": 0, "end_char": 1199, "text_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97"}
- experimental_model
- Targeted Mgp deletion
- exposure
- Mgp-null genotype
- limitations
- Loss of a protein is not isolated dietary K2 deficiency, and does not prove that extra K2 reverses established calcification.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Mice
- plain_language
- Soft tissues need active protection against inappropriate mineral deposition.
- primary_references
- [k2-p9052783] Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. (1997). https://pubmed.ncbi.nlm.nih.gov/9052783/ DOI: 10.1038/386078a0
- tissue_or_cell_type
- Arteries and cartilage
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 461–472
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted Mgp deletion · source_derived_draft · unverified_draft
### k2-mgp-arteries Mgp-null mice developed arterial calcification leading to vascular rupture and death within two months. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Soft tissues need active protection against inappropriate mineral deposition. organism: Mice tissue_or_cell_type: Arteries and cartilage experimental_model: Targeted Mgp deletion limitations: Loss of a protein is not isolated dietary K2 deficiency, and does not prove that extra K2 reverses established calcification. exposure: Mgp-null genotype evidence_span: {"source_cache": "artifacts/k2-research/9052783.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97", "start_char": 0, "end_char": 1199, "text_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97"} [k2-p9052783] Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. (1997). https://pubmed.ncbi.nlm.nih.gov/9052783/ DOI: 10.1038/386078a0
Complete structured claim and evidenceMgp deletion caused inappropriate cartilage calcification with growth-plate abnormalities, short stature, osteopenia and fractures.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/k2-research/9052783.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97", "start_char": 0, "end_char": 1199, "text_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97"}
- experimental_model
- Targeted Mgp deletion
- exposure
- Mgp-null genotype
- limitations
- Loss of a protein is not isolated dietary K2 deficiency, and does not prove that extra K2 reverses established calcification.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Mice
- plain_language
- Removing a calcification inhibitor did not simply make stronger bones.
- primary_references
- [k2-p9052783] Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. (1997). https://pubmed.ncbi.nlm.nih.gov/9052783/ DOI: 10.1038/386078a0
- tissue_or_cell_type
- Arteries and cartilage
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 474–485
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted Mgp deletion · source_derived_draft · unverified_draft
### k2-mgp-skeleton Mgp deletion caused inappropriate cartilage calcification with growth-plate abnormalities, short stature, osteopenia and fractures. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing a calcification inhibitor did not simply make stronger bones. organism: Mice tissue_or_cell_type: Arteries and cartilage experimental_model: Targeted Mgp deletion limitations: Loss of a protein is not isolated dietary K2 deficiency, and does not prove that extra K2 reverses established calcification. exposure: Mgp-null genotype evidence_span: {"source_cache": "artifacts/k2-research/9052783.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97", "start_char": 0, "end_char": 1199, "text_sha256": "3db0f618ff5c4f13affd3bb629c05ed69da28c837fc544848647afc9cfbfaf97"} [k2-p9052783] Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. (1997). https://pubmed.ncbi.nlm.nih.gov/9052783/ DOI: 10.1038/386078a0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.