Component
Mouse hepatic phosphatidylcholine/phosphatidylethanolamine ratio
Mouse hepatic phosphatidylcholine/phosphatidylethanolamine ratio. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Experimental manipulation supported a causal role for the lowered PC/PE ratio in loss of hepatocyte membrane integrity.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/choline-research/16679290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d", "start_char": 0, "end_char": 1016, "text_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d"}
- experimental_model
- Dietary depletion and Pemt/Mdr2 mouse genetics
- exposure
- Choline-deficient feeding in Pemt-null and double-null mice
- limitations
- A combined diet/genotype model; total PC amount, PC/PE ratio and membrane damage are not interchangeable measurements.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mouse, with separate human tissue comparison in the paper
- plain_language
- The balance between two membrane lipids mattered, not just one concentration.
- primary_references
- [choline-p16679290] The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. (2006). https://pubmed.ncbi.nlm.nih.gov/16679290/ DOI: 10.1016/j.cmet.2006.03.007
- tissue_or_cell_type
- Hepatic membranes
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 906–917
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary depletion and Pemt/Mdr2 mouse genetics · source_derived_draft · unverified_draft
### choline-pc-pe-membrane Experimental manipulation supported a causal role for the lowered PC/PE ratio in loss of hepatocyte membrane integrity. Condition category: nutrient_deficiency nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The balance between two membrane lipids mattered, not just one concentration. organism: Mouse, with separate human tissue comparison in the paper tissue_or_cell_type: Hepatic membranes experimental_model: Dietary depletion and Pemt/Mdr2 mouse genetics limitations: A combined diet/genotype model; total PC amount, PC/PE ratio and membrane damage are not interchangeable measurements. exposure: Choline-deficient feeding in Pemt-null and double-null mice evidence_span: {"source_cache": "artifacts/choline-research/16679290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d", "start_char": 0, "end_char": 1016, "text_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d"} [choline-p16679290] The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. (2006). https://pubmed.ncbi.nlm.nih.gov/16679290/ DOI: 10.1016/j.cmet.2006.03.007
Complete structured claim and evidence
What acts on it
Choline-deficient Pemt-null mice developed a low hepatic PC/PE ratio.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/choline-research/16679290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d", "start_char": 0, "end_char": 1016, "text_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d"}
- experimental_model
- Dietary depletion and Pemt/Mdr2 mouse genetics
- exposure
- Choline-deficient feeding in Pemt-null and double-null mice
- limitations
- A combined diet/genotype model; total PC amount, PC/PE ratio and membrane damage are not interchangeable measurements.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mouse, with separate human tissue comparison in the paper
- plain_language
- Both dietary input and endogenous synthesis were compromised.
- primary_references
- [choline-p16679290] The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. (2006). https://pubmed.ncbi.nlm.nih.gov/16679290/ DOI: 10.1016/j.cmet.2006.03.007
- tissue_or_cell_type
- Hepatic membranes
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 893–904
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary depletion and Pemt/Mdr2 mouse genetics · source_derived_draft · unverified_draft
### choline-pemt-low-ratio Choline-deficient Pemt-null mice developed a low hepatic PC/PE ratio. Condition category: nutrient_deficiency nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both dietary input and endogenous synthesis were compromised. organism: Mouse, with separate human tissue comparison in the paper tissue_or_cell_type: Hepatic membranes experimental_model: Dietary depletion and Pemt/Mdr2 mouse genetics limitations: A combined diet/genotype model; total PC amount, PC/PE ratio and membrane damage are not interchangeable measurements. exposure: Choline-deficient feeding in Pemt-null and double-null mice evidence_span: {"source_cache": "artifacts/choline-research/16679290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d", "start_char": 0, "end_char": 1016, "text_sha256": "656910ebe959c2867cac5d7cb75341ba3974ff922e584274829161326f10cf4d"} [choline-p16679290] The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. (2006). https://pubmed.ncbi.nlm.nih.gov/16679290/ DOI: 10.1016/j.cmet.2006.03.007
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.