Component
Lifespan in the UM-HET3 isoleucine-restriction study
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Isoleucine-restricted feeding beginning at six months extended lifespan in male and female genetically heterogeneous UM-HET3 mice, more strongly in males.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- UM-HET3 mice; 67% dietary isoleucine reduction with controlled diet formulation.
- limitations
- Not a human lifespan finding, and not an independent laboratory replication of all prior Lamming-group diet findings.
- nutrient_topic
- L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Isoleucine
- plain_language
- A controlled mouse study found an age- and sex-dependent longevity effect.
- primary_references
- Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37939658/ · DOI 10.1016/j.cmet.2023.10.005
L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19) · lines 418–424
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · UM-HET3 mice; 67% dietary isoleucine reduction with controlled diet formulation. · source_derived_draft · unverified_draft
## isoleucine-restriction-lifespan A controlled mouse study found an age- and sex-dependent longevity effect. Isoleucine-restricted feeding beginning at six months extended lifespan in male and female genetically heterogeneous UM-HET3 mice, more strongly in males. Model: UM-HET3 mice; 67% dietary isoleucine reduction with controlled diet formulation. Limitations: Not a human lifespan finding, and not an independent laboratory replication of all prior Lamming-group diet findings. Evidence access: Primary full text Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37939658/ · DOI 10.1016/j.cmet.2023.10.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.