Component
Mouse liver human ZIP8 overexpression state
AAV-mediated expression of human ZIP8 in mouse liver, compared with study controls.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Liver-directed human ZIP8 overexpression decreased bile manganese in mice.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Mouse liver-specific Slc39a8 deletion and liver-directed human ZIP8 overexpression
- exposure
- Liver-specific AAV-human-ZIP8 versus study controls.
- limitations
- Bile concentration is distinct from measured excretion flux.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus with human ZIP8 transgene
- plain_language
- More liver ZIP8 left less manganese in bile.
- primary_references
- [mn-trans-28481222] Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. (2017). https://pubmed.ncbi.nlm.nih.gov/28481222/ DOI: 10.1172/jci90896
- tissue_or_cell_type
- Liver, bile and measured extrahepatic tissues
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 175–186
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse liver-specific Slc39a8 deletion and liver-directed human ZIP8 overexpression · source_derived_draft · unverified_draft
### mn-trans-hepatic-zip8-overexpression-bile-mn Liver-directed human ZIP8 overexpression decreased bile manganese in mice. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: More liver ZIP8 left less manganese in bile. organism: Mus musculus with human ZIP8 transgene tissue_or_cell_type: Liver, bile and measured extrahepatic tissues experimental_model: Mouse liver-specific Slc39a8 deletion and liver-directed human ZIP8 overexpression limitations: Bile concentration is distinct from measured excretion flux. exposure: Liver-specific AAV-human-ZIP8 versus study controls. cross_nutrient: false [mn-trans-28481222] Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. (2017). https://pubmed.ncbi.nlm.nih.gov/28481222/ DOI: 10.1172/jci90896
Complete structured claim and evidenceLiver-directed AAV expression of human ZIP8 increased tissue and whole-blood manganese in mice.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Mouse liver-specific Slc39a8 deletion and liver-directed human ZIP8 overexpression
- exposure
- Liver-specific AAV-human-ZIP8 versus study controls.
- limitations
- Overexpression in mice does not establish a nutritional intervention or human dosing.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus with human ZIP8 transgene
- plain_language
- Increasing liver ZIP8 increased manganese retained in the body.
- primary_references
- [mn-trans-28481222] Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. (2017). https://pubmed.ncbi.nlm.nih.gov/28481222/ DOI: 10.1172/jci90896
- tissue_or_cell_type
- Liver, bile and measured extrahepatic tissues
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 149–160
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse liver-specific Slc39a8 deletion and liver-directed human ZIP8 overexpression · source_derived_draft · unverified_draft
### mn-trans-hepatic-zip8-overexpression-tissue-mn Liver-directed AAV expression of human ZIP8 increased tissue and whole-blood manganese in mice. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Increasing liver ZIP8 increased manganese retained in the body. organism: Mus musculus with human ZIP8 transgene tissue_or_cell_type: Liver, bile and measured extrahepatic tissues experimental_model: Mouse liver-specific Slc39a8 deletion and liver-directed human ZIP8 overexpression limitations: Overexpression in mice does not establish a nutritional intervention or human dosing. exposure: Liver-specific AAV-human-ZIP8 versus study controls. cross_nutrient: false [mn-trans-28481222] Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. (2017). https://pubmed.ncbi.nlm.nih.gov/28481222/ DOI: 10.1172/jci90896
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.