Component
Mouse blood-brain-barrier Flvcr2
Mouse blood-brain-barrier Flvcr2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The in-vivo experiments identified Flvcr2 as a major route for blood-to-brain choline uptake.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/38693257.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "39822712c47b19d59930fdb695e57814c795431132b6d8118c619dad2e1566b3", "start_char": 0, "end_char": 1335, "text_sha256": "39822712c47b19d59930fdb695e57814c795431132b6d8118c619dad2e1566b3"}
- experimental_model
- BBB expression, mouse physiology and transporter structural analysis
- exposure
- Flvcr2 perturbation and choline uptake
- limitations
- The majority-contribution result is a model result, not a universal percentage in humans. This is free-choline transport, distinct from LPC-DHA transport.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mouse in-vivo BBB experiments; construct-specific structural work
- plain_language
- Getting choline into the brain is a separate transport step from getting it into a neuron.
- primary_references
- [choline-p38693257] Structural and molecular basis of choline uptake into the brain by FLVCR2. (2024). https://pubmed.ncbi.nlm.nih.gov/38693257/ DOI: 10.1038/s41586-024-07326-y
- tissue_or_cell_type
- Blood-brain barrier endothelium
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 269–280
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · BBB expression, mouse physiology and transporter structural analysis · source_derived_draft · unverified_draft
### choline-flvcr2-brain The in-vivo experiments identified Flvcr2 as a major route for blood-to-brain choline uptake. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Getting choline into the brain is a separate transport step from getting it into a neuron. organism: Mouse in-vivo BBB experiments; construct-specific structural work tissue_or_cell_type: Blood-brain barrier endothelium experimental_model: BBB expression, mouse physiology and transporter structural analysis limitations: The majority-contribution result is a model result, not a universal percentage in humans. This is free-choline transport, distinct from LPC-DHA transport. exposure: Flvcr2 perturbation and choline uptake evidence_span: {"source_cache": "artifacts/choline-research/38693257.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "39822712c47b19d59930fdb695e57814c795431132b6d8118c619dad2e1566b3", "start_char": 0, "end_char": 1335, "text_sha256": "39822712c47b19d59930fdb695e57814c795431132b6d8118c619dad2e1566b3"} [choline-p38693257] Structural and molecular basis of choline uptake into the brain by FLVCR2. (2024). https://pubmed.ncbi.nlm.nih.gov/38693257/ DOI: 10.1038/s41586-024-07326-y
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.