Component
Leukaemogenesis in Flt3-internal-tandem-duplication mice
Progression to leukaemia in mice carrying the Flt3 internal tandem duplication.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Systemic ascorbate depletion cooperated with Flt3 internal tandem duplication to accelerate leukaemogenesis in mice, and restoring dietary ascorbate reversed that acceleration.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- duration
- To leukaemia onset
- experimental_model
- Ascorbate-depleted mice carrying Flt3 internal tandem duplication
- exposure
- Dietary ascorbate depletion, with dietary ascorbate restoration as the reversal arm
- limitations
- Depletion acted together with a leukaemic driver mutation; this is not evidence that ascorbate shortage alone causes leukaemia. The authors note possible non-cell-autonomous mechanisms.
- organism
- Mus musculus
- plain_language
- In mice already carrying a leukaemia mutation, vitamin C shortage made the disease come faster, and feeding it back undid that.
- primary_references
- [agathocleous-2017] Ascorbate regulates haematopoietic stem cell function and leukaemogenesis (2017). https://pubmed.ncbi.nlm.nih.gov/28825709/ DOI: 10.1038/nature23876
- tissue
- Haematopoietic system
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
TET2 loss and malignancy: the step between a nutrient-responsive enzyme and the disease (2026-09-23) · lines 133–141
Original AI-assisted curation of twelve primary studies located by Europe PMC title search, with every statement drafted from the retrieved abstract. Two pairs share a laboratory and are recorded as one line of evidence each. Genetic loss of function, pharmacological exposure and dietary depletion are kept as separate record types. Not publisher full text. · supports · Ascorbate-depleted mice carrying Flt3 internal tandem duplication · source_derived_draft · unverified_draft
## ascorbate-depletion-accelerates-leukaemogenesis Systemic ascorbate depletion cooperated with Flt3 internal tandem duplication to accelerate leukaemogenesis in mice, and restoring dietary ascorbate reversed that acceleration. Model/species: Ascorbate-depleted mice carrying Flt3 internal tandem duplication Organism: Mus musculus Tissue/system: Haematopoietic system Exposure: Dietary ascorbate depletion, with dietary ascorbate restoration as the reversal arm Duration: To leukaemia onset Limits: Depletion acted together with a leukaemic driver mutation; this is not evidence that ascorbate shortage alone causes leukaemia. The authors note possible non-cell-autonomous mechanisms. Primary reference: [agathocleous-2017] Ascorbate regulates haematopoietic stem cell function and leukaemogenesis (2017). https://pubmed.ncbi.nlm.nih.gov/28825709/ DOI: 10.1038/nature23876
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.