Component
Mouse fatty acid synthase / Fasn
Species, exposure, manipulation and evidence limits are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Tumor Fasn deletion abolished the growth-enhancing effect of HFCS in Apc-deficient mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- 400 microliters of 25% HFCS solution daily, approximately 3% of mouse daily calories
- duration
- 8 weeks; acute bolus for ATP analysis
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Genetically Apc-deficient mice predisposed to intestinal adenomas
- exposure_scope
- Direct HFCS in predisposed mice
- limitations
- Growth of predisposed mouse tumors, not initiation of cancer in healthy humans. Total tumor number was similar in the main comparison; human-equivalent risk is unresolved.
- nutrient_topic
- HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
- organism
- Genetically Apc-deficient mice predisposed to intestinal adenomas
- plain_language
- Tumor Fasn deletion abolished the growth-enhancing effect of HFCS in Apc-deficient mice.
- primary_references
- High-fructose corn syrup enhances intestinal tumor growth in mice. (2019). https://pubmed.ncbi.nlm.nih.gov/30898933/ DOI: 10.1126/science.aat8515
- route
- Oral gavage; Khk or Fasn deletion where specified
- tissue
- Tumor size/grade and metabolic perturbations
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 641–651
Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Genetically Apc-deficient mice predisposed to intestinal adenomas · source_derived_draft · unverified_draft
## hfcs-tumor-fasn-deletion Tumor Fasn deletion abolished the growth-enhancing effect of HFCS in Apc-deficient mice. Model/species: Genetically Apc-deficient mice predisposed to intestinal adenomas Tissue: Tumor size/grade and metabolic perturbations Exposure: 400 microliters of 25% HFCS solution daily, approximately 3% of mouse daily calories Route: Oral gavage; Khk or Fasn deletion where specified Duration: 8 weeks; acute bolus for ATP analysis Exposure scope: Direct HFCS in predisposed mice Limits: Growth of predisposed mouse tumors, not initiation of cancer in healthy humans. Total tumor number was similar in the main comparison; human-equivalent risk is unresolved. Reference: High-fructose corn syrup enhances intestinal tumor growth in mice. (2019). https://pubmed.ncbi.nlm.nih.gov/30898933/ DOI: 10.1126/science.aat8515 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.