Component
Endurance performance in the mouse ergothioneine diet experiment
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
An ergothioneine-enriched diet improved endurance performance in trained wild-type mice.
Experimental context and source evidence
- evidence_access
- Publisher abstract/introduction plus the authors' article and supplementary legends reproduced in an indexed document. This is source-derived extraction, not raw-data verification. Main-text OCR corrupts some micro-unit symbols; ambiguous doses and binding constants are deliberately not transcribed.
- experimental_condition
- control diet during the same training training · Voluntary wheel endurance training in mice Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- control diet during the same training diet enrichment · L-Ergothioneine Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "ergothioneine-enriched diet during endurance training", "comparator": "control diet during the same training", "endpoint": "wheel-running endurance performance", "effect_direction": "increase", "combination": "joint", "conditions": [{"entity_slug": "ergothioneine", "state": "diet enrichment"}, {"entity_slug": "mouse-voluntary-wheel-training", "state": "training"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Diet pre-feeding followed by voluntary wheel endurance training in mice.
- interpretation_status
- Source-derived research curation; not independent raw-data verification.
- limitations
- Diet plus training is a joint setting, not an ergothioneine-only sedentary intervention or a demonstrated human effect. The dose is not converted into a human recommendation.
- nutrient_topic
- Ergothioneine mitochondrial supplement; shared molecular requirements are not demonstrated dietary interactions. · L-Ergothioneine
- plain_language
- The target pathway has a measured mouse functional outcome.
- primary_references
- Sprenger et al. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. DOI 10.1016/j.cmet.2025.01.024; PMID 39965563; https://pubmed.ncbi.nlm.nih.gov/39965563/
- source_locator
- Figure 4B-D; Figures S5C-S5D
Ergothioneine: mitochondrial transport, MPST and sulfur-handling dependencies (2026-10-02) · lines 113–113
Original AI-assisted curation of five primary studies with publication identifiers, experimental locators and access limitations. Additive chapter supplement, not publisher full text. · supports · Diet pre-feeding followed by voluntary wheel endurance training in mice. · source_derived_draft · unverified_draft
An ergothioneine-enriched diet improved endurance performance in trained wild-type mice.
Complete structured claim and evidenceMpst-null mice showed no endurance advantage from the ergothioneine-enriched diet versus control diet.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Publisher abstract/introduction plus the authors' article and supplementary legends reproduced in an indexed document. This is source-derived extraction, not raw-data verification. Main-text OCR corrupts some micro-unit symbols; ambiguous doses and binding constants are deliberately not transcribed.
- experimental_condition
- control diet in trained Mpst-null mice training · Voluntary wheel endurance training in mice Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- control diet in trained Mpst-null mice diet enrichment · L-Ergothioneine Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- control diet in trained Mpst-null mice null · Mouse mercaptopyruvate sulfurtransferase / Mpst Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "ergothioneine-enriched diet in trained Mpst-null mice", "comparator": "control diet in trained Mpst-null mice", "endpoint": "endurance performance", "effect_direction": "no_detected_change", "combination": "joint", "conditions": [{"entity_slug": "ergothioneine", "state": "diet enrichment"}, {"entity_slug": "mouse-mpst", "state": "null"}, {"entity_slug": "mouse-voluntary-wheel-training", "state": "training"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Mpst-null mouse diet and training comparison.
- interpretation_status
- Source-derived research curation; not independent raw-data verification.
- limitations
- This is a within-genotype diet comparison during training, not evidence of dietary ergothioneine deficiency or a universal requirement for all ergothioneine effects.
- nutrient_topic
- Ergothioneine mitochondrial supplement; shared molecular requirements are not demonstrated dietary interactions. · L-Ergothioneine
- plain_language
- Removing the mouse target removed the diet-associated performance benefit.
- primary_references
- Sprenger et al. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. DOI 10.1016/j.cmet.2025.01.024; PMID 39965563; https://pubmed.ncbi.nlm.nih.gov/39965563/
- source_locator
- Figure 4G-J; Figures S5F-S5K
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Ergothioneine: mitochondrial transport, MPST and sulfur-handling dependencies (2026-10-02) · lines 121–121
Original AI-assisted curation of five primary studies with publication identifiers, experimental locators and access limitations. Additive chapter supplement, not publisher full text. · supports · Mpst-null mouse diet and training comparison. · source_derived_draft · unverified_draft
Mpst-null mice showed no endurance advantage from the ergothioneine-enriched diet versus control diet.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.