Component
Mouse dopamine D2 receptor / Drd2
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
D2 receptor deletion reduced modafinil-induced wakefulness in mice; D1-like antagonist addition abolished the residual response.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
- experimental_condition
- Wild-type modafinil exposure drug exposure · Modafinil Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Wild-type modafinil exposure deletion · Mouse dopamine D2 receptor / Drd2 Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "D2 deletion during modafinil exposure", "comparator": "Wild-type modafinil exposure", "endpoint": "D2 receptor deletion reduced modafinil-induced wakefulness in mice; D1-like antagonist addition abolished the residual response.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "mouse-drd2", "state": "deletion"}, {"entity_slug": "modafinil", "state": "drug exposure"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Mouse receptor knockout and pharmacology; antagonist effects varied with modafinil dose.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
- plain_language
- D2 receptor deletion reduced modafinil-induced wakefulness in mice; D1-like antagonist addition abolished the residual response.
- primary_references
- Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. | 2008 | DOI 10.1523/jneurosci.1819-08.2008 | PMID 18716204 | https://pubmed.ncbi.nlm.nih.gov/18716204/
- source_locator
- Reviewed reference lines 73-73; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 73–73
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Mouse receptor knockout and pharmacology; antagonist effects varied with modafinil dose. · Recorded from source · Recorded from source
In mice, D2-receptor deletion reduced modafinil-induced wakefulness. Adding a D1-like antagonist abolished the remaining response. In wild-type mice, antagonist effects depended on modafinil dose. This supports dopamine-receptor involvement, not one fixed D1/D2 contribution across exposures. Pharmacological receptor-family blockade should not automatically become proof of a unique receptor subtype or anatomical location. [Qu et al., 2008](https://pubmed.ncbi.nlm.nih.gov/18716204/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.