Component
Mouse intestinal apical Ctr1 protein abundance
Mouse intestinal apical Ctr1 protein abundance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Dietary copper limitation increased total and apically localized Ctr1 protein in mouse intestine.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/20699218.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c638594d4e707bb39a8f2e8c1fed15a42982e1dc4d525fda112d28281a853012", "start_char": 0, "end_char": 1749, "text_sha256": "c638594d4e707bb39a8f2e8c1fed15a42982e1dc4d525fda112d28281a853012"}
- experimental_model
- Intestinal immunolocalization and dietary copper limitation
- exposure
- Copper limitation in mice
- limitations
- Apical Ctr1 was observed in the examined mammalian preparations; membrane localization is model dependent and cannot be assigned universally to every human intestinal condition.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Mouse, rat and pig; human HEK293T cells for separate processing experiments
- plain_language
- The intestine increased an entry route when copper supply fell.
- primary_references
- [copper-p20699218] Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. (2010). https://pubmed.ncbi.nlm.nih.gov/20699218/ DOI: 10.1074/jbc.m110.143826
- tissue_or_cell_type
- Intestinal epithelium
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 351–362
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Intestinal immunolocalization and dietary copper limitation · source_derived_draft · unverified_draft
### copper-ctr1-intestinal-adaptation Dietary copper limitation increased total and apically localized Ctr1 protein in mouse intestine. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: The intestine increased an entry route when copper supply fell. organism: Mouse, rat and pig; human HEK293T cells for separate processing experiments tissue_or_cell_type: Intestinal epithelium experimental_model: Intestinal immunolocalization and dietary copper limitation limitations: Apical Ctr1 was observed in the examined mammalian preparations; membrane localization is model dependent and cannot be assigned universally to every human intestinal condition. exposure: Copper limitation in mice evidence_span: {"source_cache": "artifacts/copper-research/20699218.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c638594d4e707bb39a8f2e8c1fed15a42982e1dc4d525fda112d28281a853012", "start_char": 0, "end_char": 1749, "text_sha256": "c638594d4e707bb39a8f2e8c1fed15a42982e1dc4d525fda112d28281a853012"} [copper-p20699218] Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. (2010). https://pubmed.ncbi.nlm.nih.gov/20699218/ DOI: 10.1074/jbc.m110.143826
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.