Component
Mouse BV2 p65/IκB phosphorylation
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SA reduced p65 and IκB phosphorylation under LPS challenge.
Experimental context and source evidence
- evidence_access
- Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
- experimental_condition
- LPS alone added · Shikimic acid Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- LPS alone stimulus · Lipopolysaccharide Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "SA plus LPS", "comparator": "LPS alone", "endpoint": "SA reduced p65 and IκB phosphorylation under LPS challenge.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "shikimic-acid", "state": "added"}, {"entity_slug": "lipopolysaccharide", "state": "stimulus"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Mouse BV2; 10 µM SA, LPS 1 µg/mL, 1 h.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
- plain_language
- SA reduced p65 and IκB phosphorylation under LPS challenge.
- primary_references
- Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced <i>in vitro</i> and <i>in vivo</i> model. | 2023 | DOI 10.3389/fphar.2023.1265571 | PMID 38026972 | https://pubmed.ncbi.nlm.nih.gov/38026972/ | https://doi.org/10.3389/fphar.2023.1265571 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10652795/
- source_locator
- Reviewed reference lines 63-63; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 63–63
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Mouse BV2; 10 µM SA, LPS 1 µg/mL, 1 h. · source_derived_draft · unverified_draft
**Inflammatory expression and phosphorylation are distinct endpoints.** In the same BV2/LPS model, shikimic acid reduced Il6, Tnf, Nos2 and Ptgs2 transcripts at 12 h; protein/secretion measurements at 24 h also decreased. At 1 h, p65 and IκB phosphorylation decreased and IκB degradation was reduced. These changes do not establish direct inhibition of COX-2 catalysis or direct binding to every signaling protein. [Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced <i>in vitro</i> and <i>in vivo</i> model.](https://pubmed.ncbi.nlm.nih.gov/38026972/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.