Component
Mouse regional brain free D-aspartate pool
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Srr-knockout mouse forebrain had less D-aspartate without detected differences in DDO activity or L-aspartate concentrations.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Mouse frontal cortex, hippocampus and striatum; cerebellum unaffected.
- limitations
- Association supported a production hypothesis; it did not independently identify the complete biosynthetic pathway.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- A smaller pool was not explained by higher measured breakdown or lower L-aspartate.
- primary_references
- Decreased levels of free D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23439386/ · DOI 10.1016/j.neuint.2013.02.015
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 48–54
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse frontal cortex, hippocampus and striatum; cerebellum unaffected. · source_derived_draft · unverified_draft
## d-aspartate-srr-loss-ddo-control A smaller pool was not explained by higher measured breakdown or lower L-aspartate. Srr-knockout mouse forebrain had less D-aspartate without detected differences in DDO activity or L-aspartate concentrations. Model: Mouse frontal cortex, hippocampus and striatum; cerebellum unaffected. Limitations: Association supported a production hypothesis; it did not independently identify the complete biosynthetic pathway. Evidence access: Primary abstract Decreased levels of free D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23439386/ · DOI 10.1016/j.neuint.2013.02.015
Complete structured claim and evidenceSrr deletion lowered D-aspartate in mouse frontal cortex and hippocampus, while cerebellum and testes were unchanged.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Srr-knockout mice; regional amino-acid measurements.
- limitations
- Not dietary deficiency or proof that a supplement repairs the knockout.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- Dependence on the same enzyme varies by tissue.
- primary_references
- Serine racemase is involved in d-aspartate biosynthesis. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27387750/ · DOI 10.1093/jb/mvw043
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 40–46
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Srr-knockout mice; regional amino-acid measurements. · source_derived_draft · unverified_draft
## d-aspartate-srr-mouse-loss Dependence on the same enzyme varies by tissue. Srr deletion lowered D-aspartate in mouse frontal cortex and hippocampus, while cerebellum and testes were unchanged. Model: Srr-knockout mice; regional amino-acid measurements. Limitations: Not dietary deficiency or proof that a supplement repairs the knockout. Evidence access: Primary abstract Serine racemase is involved in d-aspartate biosynthesis. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27387750/ · DOI 10.1093/jb/mvw043
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.