Component
Toxicity of alpha-lipoic acid/ascorbate exposures in tumor-bearing mice
Toxicity of alpha-lipoic acid/ascorbate exposures in tumor-bearing mice. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The study reported toxicity with prolonged lipoic-acid exposure and increased toxicity with tested ascorbate combinations in mice.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/39493360.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9bd9ced1ace4214d80aad8e15ca5d61f8e4063f4e5838054b93e8c07a9550266", "start_char": 0, "end_char": 1935, "text_sha256": "9bd9ced1ace4214d80aad8e15ca5d61f8e4063f4e5838054b93e8c07a9550266"}
- experimental_model
- Cancer-cell combinations and human-tumor xenograft experiments
- exposure
- Millimolar cell exposures; injected ALA/ascorbate combinations in mice
- limitations
- Pharmacological ascorbate and animal injection exposures are not dietary vitamin C; no clinical combination trial.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Human cancer cells and mice
- plain_language
- The combination’s tolerability also needed measurement.
- primary_references
- [ala-p39493360] Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models. (2024). https://pubmed.ncbi.nlm.nih.gov/39493360/ DOI: 10.1177/11795549241283421
- tissue_or_cell_type
- Six cell lines; MDA-MB-231 xenografts
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 1105–1116
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cancer-cell combinations and human-tumor xenograft experiments · source_derived_draft · unverified_draft
### ala-ascorbate-ala-toxicity The study reported toxicity with prolonged lipoic-acid exposure and increased toxicity with tested ascorbate combinations in mice. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combination’s tolerability also needed measurement. organism: Human cancer cells and mice tissue_or_cell_type: Six cell lines; MDA-MB-231 xenografts experimental_model: Cancer-cell combinations and human-tumor xenograft experiments limitations: Pharmacological ascorbate and animal injection exposures are not dietary vitamin C; no clinical combination trial. exposure: Millimolar cell exposures; injected ALA/ascorbate combinations in mice evidence_span: {"source_cache": "artifacts/ala-research/39493360.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9bd9ced1ace4214d80aad8e15ca5d61f8e4063f4e5838054b93e8c07a9550266", "start_char": 0, "end_char": 1935, "text_sha256": "9bd9ced1ace4214d80aad8e15ca5d61f8e4063f4e5838054b93e8c07a9550266"} [ala-p39493360] Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models. (2024). https://pubmed.ncbi.nlm.nih.gov/39493360/ DOI: 10.1177/11795549241283421
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.