Component

Mouse adipocyte thermogenic gene program

Mouse adipocyte thermogenic gene program. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Inhibition of p38 MAPK activity markedly attenuated cinnamaldehyde-induced thermogenic responses in mouse adipocytes.

    Mouse p38 MAP kinase family, isoform unresolved → Mouse adipocyte thermogenic gene program source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/ceylon-research/29046261.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac", "start_char": 0, "end_char": 1763, "text_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac"}
    experimental_model
    Primary adipocyte signaling with inhibitor and knockout experiments
    exposure
    Acute and chronic purified cinnamaldehyde exposure
    limitations
    Cell thermogenesis is not a measured increase in whole-person energy expenditure or proven weight loss.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Mouse; human donor-derived adipocytes
    plain_language
    Interfering with this signaling step weakened the cellular response.
    primary_references
    [ceylon-p29046261] Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. (2017). https://pubmed.ncbi.nlm.nih.gov/29046261/ DOI: 10.1016/j.metabol.2017.08.006
    tissue_or_cell_type
    Subcutaneous adipocytes in culture
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 584–595

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary adipocyte signaling with inhibitor and knockout experiments · source_derived_draft · unverified_draft

    ### ceylon-p38-block Inhibition of p38 MAPK activity markedly attenuated cinnamaldehyde-induced thermogenic responses in mouse adipocytes. Condition category: machinery_impairment nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Interfering with this signaling step weakened the cellular response. organism: Mouse; human donor-derived adipocytes tissue_or_cell_type: Subcutaneous adipocytes in culture experimental_model: Primary adipocyte signaling with inhibitor and knockout experiments limitations: Cell thermogenesis is not a measured increase in whole-person energy expenditure or proven weight loss. exposure: Acute and chronic purified cinnamaldehyde exposure evidence_span: {"source_cache": "artifacts/ceylon-research/29046261.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac", "start_char": 0, "end_char": 1763, "text_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac"} [ceylon-p29046261] Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. (2017). https://pubmed.ncbi.nlm.nih.gov/29046261/ DOI: 10.1016/j.metabol.2017.08.006
    Complete structured claim and evidence

  2. Inhibition of PKA activity markedly attenuated cinnamaldehyde-induced thermogenic responses in mouse adipocytes.

    Mouse cAMP-dependent protein kinase family → Mouse adipocyte thermogenic gene program source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/ceylon-research/29046261.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac", "start_char": 0, "end_char": 1763, "text_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac"}
    experimental_model
    Primary adipocyte signaling with inhibitor and knockout experiments
    exposure
    Acute and chronic purified cinnamaldehyde exposure
    limitations
    Cell thermogenesis is not a measured increase in whole-person energy expenditure or proven weight loss.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Mouse; human donor-derived adipocytes
    plain_language
    Interfering with this signaling step weakened the cellular response.
    primary_references
    [ceylon-p29046261] Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. (2017). https://pubmed.ncbi.nlm.nih.gov/29046261/ DOI: 10.1016/j.metabol.2017.08.006
    tissue_or_cell_type
    Subcutaneous adipocytes in culture
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 571–582

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary adipocyte signaling with inhibitor and knockout experiments · source_derived_draft · unverified_draft

    ### ceylon-pka-block Inhibition of PKA activity markedly attenuated cinnamaldehyde-induced thermogenic responses in mouse adipocytes. Condition category: machinery_impairment nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Interfering with this signaling step weakened the cellular response. organism: Mouse; human donor-derived adipocytes tissue_or_cell_type: Subcutaneous adipocytes in culture experimental_model: Primary adipocyte signaling with inhibitor and knockout experiments limitations: Cell thermogenesis is not a measured increase in whole-person energy expenditure or proven weight loss. exposure: Acute and chronic purified cinnamaldehyde exposure evidence_span: {"source_cache": "artifacts/ceylon-research/29046261.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac", "start_char": 0, "end_char": 1763, "text_sha256": "c0e0bba821363dc1d8ecdd40d3957b7d48778605b0d72bcf9016a26466cb2aac"} [ceylon-p29046261] Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. (2017). https://pubmed.ncbi.nlm.nih.gov/29046261/ DOI: 10.1016/j.metabol.2017.08.006
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards