Component
Mouse AD-model amyloid burden
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lithium depletion increased amyloid deposition in AD-model mice.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- 3xTg and J20 mice on low-lithium diets.
- limitations
- Same study as the other depletion records, not independent replications.
- nutrient_topic
- Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
- plain_language
- Lower availability worsened an experimentally measured pathology.
- primary_references
- Lithium deficiency and the onset of Alzheimer's disease. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40770094/ · DOI 10.1038/s41586-025-09335-x
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 440–446
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 3xTg and J20 mice on low-lithium diets. · source_derived_draft · unverified_draft
## lithium-depletion-amyloid Lower availability worsened an experimentally measured pathology. Lithium depletion increased amyloid deposition in AD-model mice. Model: 3xTg and J20 mice on low-lithium diets. Limitations: Same study as the other depletion records, not independent replications. Evidence access: Primary full text Lithium deficiency and the onset of Alzheimer's disease. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40770094/ · DOI 10.1038/s41586-025-09335-x
Complete structured claim and evidenceLow-dose lithium orotate reduced amyloid pathology in the studied AD mouse models.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- 3xTg and J20 mouse regimens; matched carbonate and sodium-orotate comparisons.
- limitations
- Experimental drinking-water concentration is not a human dose; no human orotate trial is established here.
- nutrient_topic
- Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
- plain_language
- Replacement improved a model outcome.
- primary_references
- Lithium deficiency and the onset of Alzheimer's disease. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40770094/ · DOI 10.1038/s41586-025-09335-x
Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 512–518
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 3xTg and J20 mouse regimens; matched carbonate and sodium-orotate comparisons. · source_derived_draft · unverified_draft
## lithium-orotate-model-pathology Replacement improved a model outcome. Low-dose lithium orotate reduced amyloid pathology in the studied AD mouse models. Model: 3xTg and J20 mouse regimens; matched carbonate and sodium-orotate comparisons. Limitations: Experimental drinking-water concentration is not a human dose; no human orotate trial is established here. Evidence access: Primary full text Lithium deficiency and the onset of Alzheimer's disease. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40770094/ · DOI 10.1038/s41586-025-09335-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.