Component
Mouse short/branched-chain acyl-CoA dehydrogenase / Acadsb
Mus musculus SBCAD involved in branched-chain amino-acid catabolism; independent of MCAD and VLCAD.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adding FAD directly to muscle enzyme assays fully restored the depressed SBCAD activity in the Slc25a32 mutant-mouse experiments.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Flavin supply supports a distinct branched-chain amino-acid oxidation step.
- evidence_spans
- [{"source_bundle": "artifacts/riboflavin_metabolism_sources.json", "source_key": "PMC11072207", "locator": "HTML article p", "paragraph_index": 50, "char_start": 0, "char_end": 1147, "evidence_access": "full-text"}]
- experimental_model
- Slc25a32-null embryos and missense knock-in mice, isolated mitochondria and skeletal-muscle enzyme assays.
- exposure
- FAD added directly to separate acyl-CoA dehydrogenase assays.
- limitations
- In vitro rescue differs from oral riboflavin response; the most pronounced enzyme defects occurred in K235R homozygotes.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Mus musculus
- plain_language
- One amino-acid oxidation enzyme retained activity that could be restored by adding its cofactor.
- primary_references
- [peng-2022-slc25a32] Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism (2022). https://pubmed.ncbi.nlm.nih.gov/35727412/ DOI: 10.1007/s00018-022-04404-0
- tissue_or_cell_type
- Skeletal-muscle homogenates
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 930–942
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Slc25a32-null embryos and missense knock-in mice, isolated mitochondria and skeletal-muscle enzyme assays. · source_derived_draft · unverified_draft
### b2-met-mouse-sbcad-fad-rescue Adding FAD directly to muscle enzyme assays fully restored the depressed SBCAD activity in the Slc25a32 mutant-mouse experiments. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: One amino-acid oxidation enzyme retained activity that could be restored by adding its cofactor. organism: Mus musculus tissue_or_cell_type: Skeletal-muscle homogenates experimental_model: Slc25a32-null embryos and missense knock-in mice, isolated mitochondria and skeletal-muscle enzyme assays. limitations: In vitro rescue differs from oral riboflavin response; the most pronounced enzyme defects occurred in K235R homozygotes. exposure: FAD added directly to separate acyl-CoA dehydrogenase assays. cross_nutrient: Flavin supply supports a distinct branched-chain amino-acid oxidation step. evidence_spans: [{"source_bundle": "artifacts/riboflavin_metabolism_sources.json", "source_key": "PMC11072207", "locator": "HTML article p", "paragraph_index": 50, "char_start": 0, "char_end": 1147, "evidence_access": "full-text"}] [peng-2022-slc25a32] Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism (2022). https://pubmed.ncbi.nlm.nih.gov/35727412/ DOI: 10.1007/s00018-022-04404-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.